Genome Engineering With Zinc-Finger Nucleases

By D. Carroll. Genetics, 2011

963 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/a9a220b7bb119444a06ecda5acd1729662590a9c

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In Molecular Biology

Citations in the corpus

The U.S. drought of 2012 in perspective: A call to action (2013, background): “Other new technologies with potential to advance drought tolerance in crops include directed genome modification by zinc-finger nucleases (ZFNs) (Darroll, 2011), meganucleases (Gao et al.”
The CRISPR/Cas9 system produces specific and homozygous targeted gene editing in rice in one generation. (2014, background): “Later advances in the engineering of site-specific nucleases, such as zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs), have allowed more reliable targeted plant gene editing (Bogdanove and Voytas, 2011; Carroll, 2011).”
What determines growth potential and juvenile quality of farmed fish species (2013, background): “Zinc finger nucleases are powerful tools for genome editing, since they can be custom-designed to cut at specific DNA sequences (Carroll 2011; Wood et al. 2011).”
CRISPR-Cas systems for genome editing, regulation and targeting (2014, background): “220–228 (2013). 31. Wang, Y. et al. The CRISPR/Cas system mediates efficient genome engineering in Bombyx mori. Cell Res. 23, 1414–1416 (2013). np g © 2 01 4 N at ur e A m er ic a, In c.”
Delivering CRISPR: a review of the challenges and approaches (2018, background): “For an in-depth review on specific ZFN function, see the review by Carroll (2011).”
Genome Editing of Plants (2017, background): “ZFNs, in contrast, bind DNA through an engineered array of zinc finger motifs (Bibikova et al., 2003; Carroll, 2011).”
A CRISPR/Cas9 Toolbox for Multiplexed Plant Genome Editing and Transcriptional Regulation1[OPEN] (2015, background): “Historically, meganucleases or zinc finger nucleases 95 (ZFNs) have been the SSNs of choice, but they are notoriously difficult to engineer and function 96 inconsistently across different genetic loci (Carroll, 2011; Hafez and Hausner, 2012).”
Genome Editing—Principles and Applications for Functional Genomics Research and Crop Improvement (2017, background): “However, in practice, extended ZPF or TALE modules also increase the likelihood to bind off-target sites (Carroll, 2011).”