Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

By Michelle L. Christian, T. Čermák, Erin L. Doyle, Clarice L. Schmidt, Feng Zhang, Aaron W. Hummel, Adam J. Bogdanove, Daniel F. Voytas. Genetics, 2010

1,890 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ed4c2b719e5fbb45fae4cf69ebbd994aa94d167a

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Citations in the corpus

Delivering CRISPR: a review of the challenges and approaches (2018, background): “Shortly after the discovery of TALEs, TALE nucleases (TALENs) were developed that, like ZFNs, are a fusion protein comprised of a TALE and a FokI nuclease (Christian et al., 2010; Miller et al., 2011; Li et al., 2011; Reyon et al., 2012).”
CRISPR/Cas Genome Editing and Precision Plant Breeding in Agriculture. (2019, methodology): “In 2010, transcription activator-like effector nucleases (TALENs) were added to the plant genome-editing toolbox (19) (see the sidebar titled Zinc Finger Nucleases and Transcription Activator-Like Effector Nucleases).”
Genome Editing of Plants (2017, background): “TALENs are similar to ZFNs in that they have a DNA binding domain distinct from the FokI endonuclease domain (Christian et al., 2010; Bogdanove and Voytas, 2011).”
Salt resistant crop plants. (2014, background): “Designer nucleasebased approaches to alter genetic composition, such as Transcription Activator-Like Effector Nucleases (TALEN) [82–85], are reported to increase the mutagenesis efficiency of endogenous targets by specifying their binding sites with single nucleotide precision [85].”
Concerning RNA-guided gene drives for the alteration of wild populations (2014, background): “Attempts to build gene drives with more easily retargeted zinc-finger nucleases and TALENs suffered from instability due to the repetitive nature of the genes encoding them16.”
The CRISPR/Cas9 system for plant genome editing and beyond. (2015, neutral): “Until 2013, the dominant genome editing tools were zinc finger nucleases (ZFNs; Kim et al., 1996) and transcription activator-like effector nucleases (TALENs, Christian et al., 2010).”
TALENs: a widely applicable technology for targeted genome editing (2012, positive): “24 The TALEN framework was then refined by showing that nuclease activities could be greatly enhanced by truncating the length of this carboxy-terminal TALE-derived sequence 19 , 68 .”