Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors

By J. Kim, H. Zaehres, Guangming Wu, L. Gentile, Kinarm Ko, V. Sebastiano, M. Araúzo-Bravo, D. Ruau, D. Han, Martin Zenke and 1 more. Nature, 2008

992 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/32535ef9135f0b5454f1b3b4936c37f7f684e7dc

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Citations in the corpus

Epigenetic reprogramming and induced pluripotency (2009, background): “…Liver cells ND Fbx15 Aoi et al., 2008 Intestinal epithelium* ND Nanog Wernig et al., 2008 β cells 0.1-0.2% Morphology Stadtfeld et al., 2008 Ectoderm Neural progenitors <3.6% Oct4 Kim et al., 2008; Shi et al., 2008; Eminli et al., 2008 Keratinocytes* ND Nanog Wernig et al., 2008 *Secondary cells.”
Hypoxia enhances the generation of induced pluripotent stem cells. (2009, background): “(e) Counts of Nanog-GFP-positive colonies from Oct3/4 and Klf4-transduced MEFs on day 28.”
Induced pluripotency: history, mechanisms, and applications. (2010, background): “In contrast, occupancy by multiple factors (J Kim et al. 2008) leads to recruitment of the basal transcription machinery and, consequently, strong gene activation.”
Oct4-induced pluripotency in adult neural stem cells. (2009, positive): “In the case of the ESC, NSC, and two samples of the 2F iPS, we used our previous data sets (Kim et al., 2008).”
Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition (2008, background): “Fully reprogrammed iPS cells have previously been generated from fibroblasts [1,29] and other cell types [3,5,28] without a defined pre-iPS intermediate.”
A fresh look at iPS cells. (2009, background): “…mouse iPS cells have been generated from bone marrow cells (Takahashi and Yamanaka, 2006), hepatocytes and gastric epithelial cells (Aoi et al., 2008), pancreatic cells (Stadtfeld et al., 2008a), neural stem cells (Kim et al., 2008; Silva et al., 2008), and B lymphocytes (Hanna et al., 2008).”
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. (2008, background): “Recently, we and others have shown that if the target somatic cells are chosen carefully, it is possible to use an endogenously expressed reprogramming gene to help in generating iPSCs (Kim et al., 2008; Shi et al., 2008).”
Klf4 reverts developmentally programmed restriction of ground state pluripotency (2009, background): “It is apparent that the exogenous transcription factor requirements for inducing pluripotency vary with the starting cell type as do the efficiency and kinetics of molecular reprogramming (Aoi et al., 2008; Kim et al., 2008; Silva et al., 2008).”
Nanog Is the Gateway to the Pluripotent Ground State (2009, positive): “This restricted expression of Nanog is associated with and essential for prosecuting the transition to pluripotency in a subset of cells that already express Oct4 and Sox2.”