A fresh look at iPS cells.

By S. Yamanaka. Cell, 2009

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Nuclear reprogramming to a pluripotent state by three approaches (2010, background): “A pluripotent stem-cell state has now been induced in a plethora of differentiated cell types, including pancreatic β cells, keratinocytes, hepatocytes and stomach cell”
Risk factors in the development of stem cell therapy (2011, background): “Furthermore it has been suggested that sustained expression of the reprogramming transgenes might suppress differentiation of iPSCs which may result in an increased tendency to teratoma formation when these cells are transplanted into patients [76].”
Reprogramming of human primary somatic cells by OCT4 and chemical compounds. (2010, background): “Various strategies have been developed to generate iPSCs with fewer or no exogenous genetic manipulations, which represent a major hurdle for iPSC applications (Yamanaka, 2009).”
Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. (2010, background): “Vitamin C Improves the Generation of Human iPSCs Reprogramming is more challenging in human cells, raising a barrier for producing iPSCs and concerns about the quality and homogeneity of clones that do arise (Yamanaka, 2009).”
Incomplete DNA methylation underlies a transcriptional memory of the somatic cell in human iPS cells (2011, neutral): “dtd" [ ]> Human iPS cells can be derived from differentiated cells by activation of key transcription factors and hold enormous promise in regenerative medicin”