Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.

By Yan Shi, C. Desponts, J. Do, H. S. Hahm, Hans Robert Schöler, Sheng Ding. Cell Stem Cell, 2008

1,011 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5c27f67b0c7626c7c97d096bf02be34342268d48

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In Developmental Neuroscience

K. Hochedlinger

In Molecular Biology

Citations in the corpus

Epigenetic reprogramming and induced pluripotency (2009, background): “…are implicated in the silencing of Oct4 and other pluripotency genes – histone deacetylation, histone methylation and DNA methylation – improves the efficiency of transcription factorinduced reprogramming (Huangfu et al., 2008a; Huangfu et al., 2008b; Mikkelsen et al., 2008; Shi et al., 2008b).”
Mammalian Krüppel-Like Factors in Health and Diseases (2010, background): “The requirement for Oct4 and Klf4 in reprogramming somatic cells has been substantiated (110, 372).”
Parkinson’s Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors (2009, background): “Screens to replace the reprogramming factors in the mouse and in the human system have led to the replacement of single factors (Huangfu et al., 2008; Shi et al., 2008a, 2008b).”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “In a chemical compound screen, an inhibitor of G9a histone methyltransferase BIX-01294 was found to improve reprogramming of mouse neural progenitor cells transduced with Oct4 and Klf4 (8- fold)(Shi et al., 2008b).”
Molecular maps of the reorganization of genome – nuclear lamina interactions during differentiation (2010, background): “Indeed, inhibition of DNA methyltransferase or histone deacetylases facilitates the reprogramming of differentiated cells into ESCs (Huangfu et al., 2008; Mikkelsen et al., 2008; Shi et al., 2008).”
In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer’s disease model (2013, background): “In Vivo Glia-Neuron Conversion after Injury and AD Shi et al., 2008).”
Hypoxia enhances the generation of induced pluripotent stem cells. (2009, background): “Recently, small-molecule compounds have been reported to enable the reprogramming of Oct3/4 and Klf4-transduced MEFs to iPS cells (Shi et al., 2008a).”