Free radical-induced damage to DNA: mechanisms and measurement.

By M. Dizdaroglu, P. Jaruga, M. Birincioglu, H. Rodriguez. Free Radical Biology & Medicine, 2002

951 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3152b99543410b5465a2da045c8e30a0c43eebb8

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Citations in the corpus

Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean? (2004, background): “Such products can be measured by HPLC, gas chromatography (GC)–MS, liquid chromatography (LC)–MS and antibody-based techniques, and arguments rage over which is best (Halliwell, 1999b, 2000c; Dizdaroglu et al., 2002; Kasai, 2002; Collins et al., 2004).”
Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans (2017, background): “Oxidation of DNA components by ROS/RNS is the major source of induced DNA damages leading to several types of DNA modifications including nucleotide oxidation, strand breakage, loss of bases, and adduct formation [161, 162].”
Biomarkers of oxidative damage in human disease. (2006, methodology): “Hence, urinary 8OHdG is a partial measure of damage to guanine residues in DNA and its nucleotide precursor pool, and 8OHdG concentrations may not truly reflect rates of oxidative damage to DNA (149).”
Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases (2014, background): “The other free radical induced adducts of DNA bases include, 5-formyl uracil, cytosine glycol, 5,6-dihydrothyronine, 5-hydroxy-6-hydro-cytosine, 5-hydroxy-6-hydro uracil, uracil glycol, and alloxan [72].”
Studies on free radicals, antioxidants, and co-factors (2007, background): “Further evidence of the involvement of free radicals comes from the fact that oxidative stress is responsible for the initiation of nigral dopamine neuron loss.”
Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretation. (2009, background): “…& Bravo (2007); 12: Del Rio et al. (2005); 13: Freitas et al. (2007); 14: Steghens et al. (2001); 15: Larstad et al. (2002); 16: Karatas et al. (2002); 17: Guetens et al. (2002); 18: Dizdaroglu et al. (2002); 19: Cadet et al. 2003; 20: Selman et al. (2006); 21: Collins (2007); 22: Selman et al. ).”
Oxidative Stress, Mitochondrial Dysfunction, and Aging (2011, background): “7,8-dihydro-8-oxodeoxyguanosine (8-oxo-dG) is one of the most abundant and well-characterized DNA lesions caused by ROS [36].”
A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. (2013, background): “The peroxyl and OH-radicals also intervene in DNA oxidation (Dizdaroglu et al., 2002; Valko et al., 2004).”
Assessment of antioxidant capacity in vitro and in vivo. (2010, positive): “Oxidation products of lipids [125,153–157], oxidative modification and expression of proteins and sugars [158,159], strand breaks of DNA and oxidation products of DNA bases [160] have been used as oxidative stress biomarkers.”
Advances in metal-induced oxidative stress and human disease. (2011, background): “To date,more than 100 oxidative products of DNA have been identified, the best known being of 8-hydroxyguanine (8-OH-G) (Dizdaroglu et al., 2002; England et al., 1998) (see Fig.”