Light-activated ion channels for remote control of neuronal firing

By Matthew R. Banghart, Katharine Borges, E. Isacoff, Dirk Trauner, R. Kramer. Nature Neuroscience, 2004

686 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/2e5e47f50952fa54b293a8e985fd89982ed373dc

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Citations in the corpus

Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration. (2006, neutral): “As part of an effort to improve the temporal resolution, recently a light-sensitive K+ channel was engineered (Banghart et al., 2004).”
Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits (2006, background): “Over the past several years, several approaches for optical control of neuronal activity have been developed (Zemelman et al., 2002, 2003; Banghart et al., 2004; Boyden et al., 2005; Lima and Miesenböck, 2005; Schroll et al., cell (which is generally not the case) and even if the scale of the CNS…”
Channelrhodopsin-2 and optical control of excitable cells (2006, background): “…‘uncaging’ of chemically modified signaling molecules 9–11 , chemical modification of ion channels and receptors to render them light-responsive 12,13 and introduction of light-sensitive proteins into otherwise light-insensitive cells 5–8, 11 Light-mediated uncaging of signaling molecules.”
Light-induced activation of distinct modulatory neurons triggers appetitive or aversive learning in Drosophila larvae. (2006, neutral): “, the necessity to coexpress multiple genes [16] or the requirement of acute injection of chemical compounds [17, 18].”
The Development and Application of Optogenetics (2011, methodology): “…of caged agonists, were developed for Drosophila experiments (Lima & Miesenbock 2005, Zemelman et al. 2003); and UV light– isomerizable chemicals linked to genetically encoded channels were employed in cultured cells and in zebrafish (Banghart et al. 2004, Szobota et al. 2007, Volgraf et al. 2006).”
Multimodal fast optical interrogation of neural circuitry (2007, background): “Author Information The GenBank accession number is EF474018 for the ‘mammalianized’ NpHR sequence and EF474017 for the ‘mammalianized’ ChR2(1-315) sequence.”
An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology (2007, background): “Leveraging advances in chemical biology and molecular genetics, several groups have developed novel optical techniques to control neural activity, involving optical uncaging of chemically modified neurotransmitters [25–27], chemical modification of native proteins to render them light-responsive [28”
Millisecond-timescale, genetically targeted optical control of neural activity (2005, methodology): “Furthermore, previous genetically encoded optical methods, although elegan”
Caged compounds: photorelease technology for control of cellular chemistry and physiology (2007, neutral): “Recently techniques for photochemical switching of ion channel conductio”