Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration.

By A. Bi, J. Cui, Yu-ping Ma, E. Olshevskaya, M. Pu, A. Dizhoor, Z. Pan. Neuron, 2006

726 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6d34e56182bd6c84d0c3c66c9cdede1cb2b815ec

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

Multimodal fast optical interrogation of neural circuitry (2007, background): “Author Information The GenBank accession number is EF474018 for the ‘mammalianized’ NpHR sequence and EF474017 for the ‘mammalianized’ ChR2(1-315) sequence.”
Molecular and cellular approaches for diversifying and extending optogenetics. (2010, background): “…of the optogenetic approach across animal species (Adamantidis et al., 2007; Airan et al., 2009; Aravanis et al., 2007; Arenkiel et al., 2007; Bi et al., 2006; Boyden et al., 2005; Chow et al., 2010; Douglass et al., 2008; Gradinaru et al., 2008, 2009; Hägglund et al., 2010; Han et al.,…”
Multiple-Color Optical Activation, Silencing, and Desynchronization of Neural Activity, with Single-Spike Temporal Resolution (2007, background): “ChR2 has already proven to be well-tolerated in intact mammalian neural circuits–up to a year, the longest time yet described in a publication [29]; if Halo gains a similar track record, it is possible that Halo-enabled prosthetics may open up new horizons in controlling disorders of excitable cells”
In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. (2007, background): “Recent in vitro, in ovo, and viral transduction studies have revealed the light-gated ion channel Channelrhodopsin-2 (ChR2) as a potentially ideal candidate for this approach (Nagel et al., 2003, 2005b; Boyden et al., 2005; Li et al., 2005; Bi et al., 2006; Zhang and Oertner, 2007).”
Characterization of engineered channelrhodopsin variants with improved properties and kinetics. (2009, background): “Several studies have demonstrated the utility of ChR2 for mapping neurocircuitry (3,6), inducing synaptic plasticity (7), restoring vision in rhodopsin-deficient animals ( 5 ), and studying behavior in free-moving animals (8).”
Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits (2006, neutral): “3) (Li et al., 2005; Bi et al., 2006; Ishizuka et al., 2006; Zhang et al., 2006).”
Micro-LED arrays: a tool for two-dimensional neuron stimulation (2008, background): “On the other hand, Bi et al reported later that a power density of only 50 pW µm−2 was sufficient to stimulate ChR2 expressing mice retinal neuron cells (Bi et al 2006)—a difference of three orders of magnitude.”
Channelrhodopsin-2 and optical control of excitable cells (2006, background): “In the spirit of applying photostimulation to address biomedical needs, a recent study demonstrated that expression of ChR2 in the retina of a mouse with photoreceptor degeneration restored the retina’s ability to transduce light signals and relay information to the visual cortex 38 .”