Light-induced activation of distinct modulatory neurons triggers appetitive or aversive learning in Drosophila larvae.

By C. Schroll, T. Riemensperger, D. Bucher, Julia Ehmer, T. Völler, K. Erbguth, B. Gerber, T. Hendel, G. Nagel, E. Buchner and 1 more. 2006

613 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Insect Science

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Citations in the corpus

Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila (2014, background): “Recent studies of dopamine signaling have implicated distinct sites of memory formation within the MB lobes (summarized in Figure 1A) (Schroll et al., 2006; Claridge-Chang et al., 2009; Aso et al., 2010, 2012; Burke et al., 2012; Liu et al., 2012; Perisse et al., 2013).”
The neuronal architecture of the mushroom body provides a logic for associative learning (2014, background): “…et al., 2003; Aso et al., 2010, 2012; Burke et al., 2012; Liu et al., 2012) and exogenous activation of DAN subpopulations can serve as an US in associative learning paradigms (Schroll et al., 2006; Claridge-Chang et al., 2009; Aso et al., 2010, 2012; Burke et al., 2012; Liu et al., 2012).”
WRITING MEMORIES WITH LIGHT-ADDRESSABLE REINFORCEMENT CIRCUITRY (2009, background): “Second, although experiments in larvae point to an instructive role in memory formation (Schroll et al., 2006), it is unconfirmed”
Multiple-Color Optical Activation, Silencing, and Desynchronization of Neural Activity, with Single-Spike Temporal Resolution (2007, methodology): “Laboratories working on classical neural model organisms such as Drosophila and C. elegans have devised ways of delivering all-trans-retinal to the nervous systems of such animals in order to enable ChR2 function [54, 55 ], and these protocols would therefore also enable the function of Halo in thes”
Pain-relief learning in flies, rats, and man: basic research and applied perspectives (2014, background): “…the TDC-Gal4 expression pattern to drive octopaminergic neurons, or the tbHM18 mutant (CG1543) to impair octopamine biosynthesis, have www.learnmem.org 233 Learning & Memory corresponding net effects in the appetitive domain (e.g., Schwaerzel et al. 2003; Schroll et al. 2006; Burke et al. 2012).”
Independent Optical Excitation of Distinct Neural Populations (2014, background): “The number of pulses (25) and the frequency (40 Hz) were fixed.”
The complete connectome of a learning and memory centre in an insect brain (2017, methodology): “Previous studies in the larva have shown that odor paired with activation of medial and vertical lobe DANs leads to learned approach 8 and avoidance 7;42 , respectively.”
Do the right thing: neural network mechanisms of memory formation, expression and update in Drosophila (2018, background): “The presynaptic terminals of different subsets of dopaminergic neurons (DANs), encoding positive or negative valence, occupy distinct, nonoverlapping compartments of the mushroom body neuropil which are precisely matched by the dendritic fields of discrete MBONs (Figure 1) [16,18,19,22,23,34 ,35,36]”
Motor control in a Drosophila taste circuit (2009, methodology): “ChR2 has been used effectively in C. elegans, Drosophila, and mammals to precisely activate neural subsets and generate behaviors (Arenkiel et al., 2007; Nagel et al., 2005; Schroll et al., 2006; Zhang et al., 2007a, 2007b).”
Neuronal assemblies of the Drosophila mushroom body (2008, background): “In the Drosophila MB, octopaminergic and dopaminergic neurons are suggested to send rewarding and punishing signals, respectively (Schwaerzel et al., 2003; Schroll et al., 2006).”