Multimodal fast optical interrogation of neural circuitry

By Feng Zhang, Liping Wang, M. Brauner, J. Liewald, Kenneth Kay, N. Watzke, P. Wood, E. Bamberg, G. Nagel, A. Gottschalk and 1 more. Nature, 2007

1,753 citations recorded by the source corpus.

Subfields: Atomic and Molecular Physics, and Optics, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/d45636b0ef5d90659c0079568e746f2801954ee7

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In Atomic and Molecular Physics, and Optics

Karl Deisseroth

In Cellular and Molecular Neuroscience

Citations in the corpus

Differential control of learning and anxiety along the dorso-ventral axis of the dentate gyrus (2013, methodology): “Using optogenetic techniques to either elevate or decrease GC activity, we demonstrate that GCs in the dorsal DG control exploratory drive and encoding, not retrieval, of contextual fear memories.”
Burst timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons: A putative cellular substrate for reward learning (2009, positive): “selectively targeted the light-activated gene channelrhodopsin-2 (ChR2) (Arenkiel et al., 2007; Boyden et al., 2005; Zhang et al., 2006; Zhang et al., 2007) to DA neurons via the tyrosine hydroxylase gene in Cre transgenic animals with local injection of adenoassociated virus.”
Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins (2011, background): “(iv) Finally the nature of the action spectrum will dictate feasibility of combining with other light-activated reagents in the same preparatio”
Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. (2009, neutral): “in Transgenic Mice Expressing Evolved”
Application of machine learning to epileptic seizure onset detection and treatment (2009, background): “A therapeutic system capable of detecting and reacting to the onset of a seizure could administer a local electrical [60], thermal [47], or neurochemical [69] stimulus that”
Synaptic plasticity and addiction (2007, background): “Additional molecular approaches, such as the restricted expression of light-activated ion channels and pumps that depolarize or hyperpolarize neuron”
Remote Excitation of Neuronal Circuits Using Low-Intensity, Low-Frequency Ultrasound (2008, neutral): “and synapses in intact brain circuits [2].”
Optogenetic tools for analyzing the neural circuits of behavior (2011, methodology): “Multiple opsins can be expressed in the same cell; for example, a cell expressing both a channelrhodopsin and a halorhodopsin [28,29], perhaps linked by a ribosomal skip peptide [71,72], can be depolarized by blue light and hyperpolarized by yellow light.”
Circuit-breakers: optical technologies for probing neural signals and systems (2007, background): “To better understand the contribution of specific cell types to the physiology of neuropsychiatric disease, a pair of microbial light-sensitive proteins have been developed that, when used togther, can optically interrogate intact neural circuits and bidirectionally control animal behaviou”