Millisecond-timescale, genetically targeted optical control of neural activity

By Ed Boyden, Feng Zhang, E. Bamberg, G. Nagel, Karl Deisseroth. Nature Neuroscience, 2005

4,714 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/0e8831ea98594450e3dab2d0b9e0a31b15941497

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Light-induced activation of distinct modulatory neurons triggers appetitive or aversive learning in Drosophila larvae. (2006, neutral): “When expressed in cultured hippocampal neurons, light flashes evoke action potentials controllable at a millisecond timescale [20].”
Differential control of learning and anxiety along the dorso-ventral axis of the dentate gyrus (2013, background): “0-YFP [Madisen et al., 2012]) or the blue light-activated cation channel channelrhodopsin (ChR2) (Boyden et al., 2005) (ROSA26-CAG-stopflox-ChR2(H134R)tdTomato [Madisen et al., 2012]; Figures 1A and 1E).”
Super-resolution Imaging of Chemical Synapses in the Brain (2010, positive): “We then tested whether the receptor composition in AOB synapses could be modulated by neural activity using an optogenetic approach (Boyden et al., 2005).”
Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses. (2005, background): “9 s (n = 3), as similarly observed in oocytes [3] and rat neurons [8].”
The molecular and systems biology of memory. (2014, positive): “Using the cfos-based genetic tagging approach they expressed channelrhodopsin (ChR2) (Boyden et al., 2005), specifically in neurons that were activated during learning in a contextual fear-conditioning task (Figure 3).”
Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. (2009, positive): “The development of genetic and optical tools to visualize and activate neuronal activity with exquisite temporal resolution using microbial opsins (e.g., channelrhodopsin-2, halorhodopsin, Volvox carteri channelrhodopsin, optoXRs) has provided an expanding toolbox for decoding the neuronal correlate”