Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss.

By Jean-Philippe Bastard, Claude Jardel, Eric Bruckert, P. Blondy, Jacqueline Capeau, Martine Laville, Hubert Vidal, Bernard Hainque. Journal of Clinical Endocrinology and Metabolism, 2000

1,181 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/2b111d06405bcc3fa66829a9d59f3a623e4cc659

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Citations in the corpus

Recent advances in the relationship between obesity, inflammation, and insulin resistance. (2006, background): “Recent studies have suggested that IL-6 could be involved in insulin resistance and its complications [6, 63].”
Muscle as an endocrine organ: focus on muscle-derived interleukin-6. (2008, background): “Given this proinflammatory response and the observation that systemic IL-6 concentrations are elevated in obesity and in patients with type 2 diabetes (21, 51, 377), it is generally thought that elevations in the plasma and/or tissue concentrations of IL-6 have a negative effect on metabolism (190).”
Insulin resistance and chronic cardiovascular inflammatory syndrome. (2003, neutral): “Insulin sensitivity has been evaluated using euglycemic clamp technique (231, 232), the minimal model approach (51, 233), or the fasting insulin resistance index (51, 234).”
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes. (2014, background): “shown to be reduced when these patients are engaged in a more intensive lifestyle causing weight loss [6-11].”
Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. (2003, background): “7), all of which have been reported to be affected by weight loss in obese subjects (2, 5, 11) and therefore could be of importance as part of the link between obesity and health complications (e.”
Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ (2001, neutral): “1998, 1999; Bastard et al .”
Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. (2004, background): “The level of physical activity increased more in the intervention group (from 48 [10] to 195 [36] min/wk) than in the control group (from 51 [9] to 84 [28] min/ wk; P .”
The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. (2004, background): “Interleukin-6 (IL-6) is also secreted by adipocytes, and its concentrations have been positively related to adiposity and negatively related to insulin action (46,47).”
Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. (2002, methodology): “Moreover, we and others recently observed a significant correlation between circulating IL-6 levels and insulin sensitivity assessed by the fasting insulin resistance index or by an iv glucose tolerance test with minimal model analysis (12, 18, 19).”
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, neutral): “Circulating levels of IL-6 are increased in obese subjects and are reduced with insulin sensitizing therapies (56, 376).”
Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines (2013, positive): “Similarly to TNF-α, WAT and plasma IL-6 expression correlate with increased body mass, waist circumference, and free fatty acid levels [30], with reduction in circulating IL-6 following weight loss [31].”
A population-based dietary inflammatory index predicts levels of C-reactive protein in the Seasonal Variation of Blood Cholesterol Study (SEASONS) (2013, background): “Public Health Nutrition: 17(8), 1825–1833 doi:10.”
Dietary factors and low-grade inflammation in relation to overweight and obesity (2011, neutral): “Such changes have been described for CRP((112)), IL-6((113)), IL-18((114)), IL-1ra((26)), PAI-1((115)), SAA((23,116)), cathepsin S((117)), matrix metalloproteinase-9((118)), soluble adhesion mol-”
Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “, decreased pro-inflammatory factors and increased antiinflammatory molecules) and regulate inflammation-related genes in white adipose tissue (Bastard et al., 2000; Clement et al., 2004; Cancello et al., 2005; Forsythe et al., 2008).”