Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro.

By J. Bastard, M. Maachi, J. T. van Nhieu, C. Jardel, E. Bruckert, A. Grímaldi, J. Robert, J. Capeau, B. Hainque. Journal of Clinical Endocrinology and Metabolism, 2002

666 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/9d7ca883aacbe7e8ba3e5313ce3677b6ab5bd15f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. Haiming Cao
2. José Fernández-Real
3. W. Ricart
4. B. K. Pedersen
5. A. M. Petersen
6. Barry M. Popkin

In Epidemiology

1. Haiming Cao
2. A. M. Petersen
3. José Fernández-Real
4. J. Bastard
5. Myung‐Sook Choi
6. W. Ricart
7. B. K. Pedersen
8. U. Jung

In Physiology

1. Haiming Cao
2. A. M. Petersen
3. M. Qatanani
4. Myung‐Sook Choi
5. B. K. Pedersen
6. U. Jung
7. Mitchell A. Lazar
8. Barry M. Popkin

Citations in the corpus

• Psoriasis and systemic inflammatory diseases: potential mechanistic links between skin disease and co-morbid conditions. (2010, background): “, 2003; Bernotiene et al., 2006). In light of the above activities, leptin has been implicated in the pathogenesis of immune-mediated inflammatory diseases (IMIDs) such as type 1 diabetes, rheumatoid arthritis (RA), inflammatory bowel disease, and psoriasis (Trayhurn, 2005). Hamminga et al. (2006) h”
• Adipocytokines in Obesity and Metabolic Disease (2014, positive): “In patient studies, increased serum IL6 correlates with obesity and insulin resistance (Vozarova et al. 2001, Bastard et al. 2002, Spranger et al. 2003).”
• Adipokines: the missing link between insulin resistance and obesity. (2008, background): “[32] Bastard JP, Maachi M, Tran Van Nhieu J, Jardel C, Bruckert E, Grimaldi A, et al.”
• Mechanisms of obesity-associated insulin resistance: many choices on the menu. (2007, background): “Adipose tissue IL-6 expression accounts for ∼30% of systemic IL-6, and circulating IL-6 concentrations are positively correlated with obesity, impaired glucose tolerance, and insulin resistance (Bastard et al. 2002).”
• Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease (2014, background): “Expression of adipose IL-6 positively correlates with insulin resistance both in vivo and in vitro [96].”
• Role of interleukin-6 in cancer progression and therapeutic resistance (2016, neutral): “causing hyperlipidaemia and hyperglycaemia [56].”
• Recent advances in the relationship between obesity, inflammation, and insulin resistance. (2006, background): “Recent studies have suggested that IL-6 could be involved in insulin resistance and its complications [6, 63].”
• Insulin resistance and chronic cardiovascular inflammatory syndrome. (2003, positive): “All of these findings are strengthened by the recent description of IL-6 receptors in human adipocytes (235) and by the demonstration that IL-6 impairs insulin signaling in primary mouse hepatocytes and human hepatocarcinoma cell line, HepG2 (236).”
• The anti-inflammatory effect of exercise. (2005, background): “In humans, circulating IL-6 levels may (6, 107) or may not (18, 106) be associated with insulin resistance.”