Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
By Christian K. Roberts, A. Hevener, R. Barnard. Comprehensive Physiology, 2013
729 citations recorded by the source corpus.
Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity, insulin resistance, hypertension, and dyslipidemia. Although there has been significant debate regarding the criteria and concept of the syndrome, this clustering of risk factors is unequivocally linked to an increased risk of developing type 2 diabetes and cardiovascular disease. Regardless of the true definition, based on current population estimates, nearly 100 million have MS. It is often characterized by insulin resistance, which some have suggested is a major underpinning link between physical inactivity and MS. The purpose of this review is to: (i) provide an overview of the history, causes and clinical aspects of MS, (ii) review the molecular mechanisms of insulin action and the causes of insulin resistance, and (iii) discuss the epidemiological and intervention data on the effects of exercise on MS and insulin sensitivity. © 2013 American Physiological Society. Compr Physiol 3:1‐58, 2013.
Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/106b3260bfb4b2ce169fe8746222f9f0320a3047
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Endocrinology, Diabetes and Metabolism
In Epidemiology
In Physiology
Citations in the corpus
- Physical activity in older age: perspectives for healthy ageing and frailty (2016, background): “…fatty acid oxidation in skeletal muscle, rather than accumulating intramuscular and adipose tissue stores around themajor organs aswell as lowered blood pressure helps to reduce the risk of developing type 2 diabetes mellitus and cardiovascular disease (Roberts et al. 2013; Stewart et al. 2005).”
- Trends in insulin resistance: insights into mechanisms and therapeutic strategy (2022, methodology): “THE DIAGNOSIS AND THERAPEUTIC STRATEGY OF IR Diagnosis methods of IR As we all know, IR is related to several metabolic abnormalities including obesity, glucose tolerance, dyslipidemia, type 2 diabetes and other metabolic syndrome.(429,430) Several methods are used to measure blood insulin levels th”
- Pathogenesis of Type 2 Diabetes Mellitus (2015, background): “These are exacerbated by genetic predisposi‐ tion but IR could be reduced with minimizing dietary intake and regular exercise [27].”