Adipose Tissue in Obesity-Related Inflammation and Insulin Resistance: Cells, Cytokines, and Chemokines
By Kassem Makki, Philippe Froguel, I. Wolowczuk. ISRN Inflammation, 2013
1,015 citations recorded by the source corpus.
Adipose tissue is a complex organ that comprises a wide range of cell types with diverse energy storage, metabolic regulation, and neuroendocrine and immune functions. Because it contains various immune cells, either adaptive (B and T lymphocytes; such as regulatory T cells) or innate (mostly macrophages and, more recently identified, myeloid-derived suppressor cells), the adipose tissue is now considered as a bona fide immune organ, at the cross-road between metabolism and immunity. Adipose tissue disorders, such as those encountered in obesity and lipodystrophy, cause alterations to adipose tissue distribution and function with broad effects on cytokine, chemokine, and hormone expression, on lipid storage, and on the composition of adipose-resident immune cell populations. The resulting changes appear to induce profound consequences for basal systemic inflammation and insulin sensitivity. The purpose of this review is to synthesize the current literature on adipose cell composition remodeling in obesity, which shows how adipose-resident immune cells regulate inflammation and insulin resistance—notably through cytokine and chemokine secretion—and highlights major research questions in the field.
Subfields: Epidemiology, Immunology, Physiology
View Paper: https://www.semanticscholar.org/paper/44fcca459a72d02cc8a47e6e612900e032456d24
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Citations in the corpus
- Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders (2016, background): “In addition, pro-inflammatory cytokines stimulate lipolysis in adipocytes, leading to lipotoxicity in other tissues (2, 3).”
- Flavonoids and Their Anti-Diabetic Effects: Cellular Mechanisms and Effects to Improve Blood Sugar Levels (2019, background): “It also inhibits the expression of multiple pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNG-α), which promotes lipolysis and increases FFAs production [32].”