Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans.

By J. Bruun, A. S. Lihn, C. Verdich, S. Pedersen, S. Toubro, A. Astrup, B. Richelsen. American Journal of Physiology. Endocrinology and Metabolism, 2003

823 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/4cb06302142f7ef234d4471756ca64f2fb12aa22

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Herbert Tilg
2. A. Moschen
3. J. Bastard
4. Jaswinder K. Sethi
5. M. Ibrahim
6. B. Fève
7. W. Cawthorn

In Physiology

1. Herbert Tilg
2. Jaswinder K. Sethi
3. M. Ibrahim
4. C. Mantzoros
5. W. Cawthorn
6. A. Moschen

Citations in the corpus

• Adiponectin Regulation and Function (2018, neutral): “In all of these cases, increases in adiponectin were correlated with improved insulin sensitivity (23,387).”
• TNF-α and adipocyte biology (2007, background): “dyslipidaemia by suppressing the production of adiponectin [63,109–111]; indeed, circulating levels of adiponectin inversely correlate with plasma levels of TNF-a [112,113].”
• Obesity and cancer risk: Emerging biological mechanisms and perspectives. (2019, background): “Adiponectinemia has an inverse correlation with inflammatory cytokines which are elevated in obesity, such as tumor necrosis factor-α (TNF-a) and interleukin (IL)-6; it can also attenuate nuclear factor-κB (NF-kB) activation [103].”
• Subcutaneous and visceral adipose tissue: structural and functional differences (2010, background): “Interlukins and TNF-a are potent inhibitors of adiponectin expression and secretion in human white adipose tissue (30).”
• Inflammatory Mechanisms in the Regulation of Insulin Resistance (2008, background): “Weight loss induces adiponectin synthesis (37), as activation of peroxisome-proliferator– activated receptor γ (PPARγ) by its ligands thiazolidinediones (TZDs), which are used in the treatment of T2D (38).”
• Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. (2009, background): “This may be attributable to inhibition of adiponectin gene transcription by inflammatory and angiogenic factors secreted by hypertrophic adipocytes.(3,4) Currently, theprevalenceof type2diabetes in the United States and many other countries in the world has reached epidemic proportions.”
• Relationship between adipocyte size and adipokine expression and secretion. (2007, background): “TNF- , IL-6, or IL-8 (64, 65), which are released from surrounding cells, particularly preadipocytes and macrophages.”
• Obesity and the role of adipose tissue in inflammation and metabolism. (2006, background): “Certain cytokines are thought to reduce adiponectin expression (53).”
• Adipokines: the missing link between insulin resistance and obesity. (2008, background): “On the other hand, adipoectin expression in human adipocytes is reduced by TNF- and L-6 [50].”
• Recent advances in the relationship between obesity, inflammation, and insulin resistance. (2006, background): “By contrast both TNF-a and IL-6 reduce human adipocyte mRNA expression of adiponectin [78], which is an additional mechanism by which these two cytokines induce insulin resistance.”