Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus.

By J. Snyder, N. Kee, J. Martin Wojtowicz. 2001

649 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Fred H. Gage
2. James Bradley Aimone
3. Hongjun Song
4. Guo-li Ming
5. E. Gould
6. R. Hen
7. Wei Deng
8. Chunmei Zhao

In Cognitive Neuroscience

1. Fred H. Gage
2. James Bradley Aimone
3. Hongjun Song
4. Guo-li Ming
5. R. Hen
6. Wei Deng
7. A. F. Schinder
8. J. Snyder

In Developmental Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. James Bradley Aimone
4. Guo-li Ming
5. Wei Deng
6. R. Hen
7. E. Gould
8. Chunmei Zhao

Citations in the corpus

• Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Furthermore, NR2B is specially required for enhanced synaptic plasticity of newborn dentate granule cells during the critical period (Figure 3B) (Ge et al., 2007; Snyder et al., 2001).”
• Learning Enhances the Survival of New Neurons beyond the Time when the Hippocampus Is Required for Memory (2004, background): “For example, they rapidly extend mossy fibers into area CA3 (Hastings and Gould, 1999) and exhibit robust long-term potentiation that, unlike mature granule cells, is insensitive to GABAergic inhibition (Wang et al., 2000; Snyder et al., 2001; Schmidt-Heber et al., 2004).”
• Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network (2012, positive): “Indeed, previous studies showed a lower threshold for long-term potentiation (LTP) induction in young neurons, which depends in part on the expression of T type calcium channels and NR2B-containing NMDA receptors (2, 12, 21, 22).”
• The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis. (2002, methodology): “It was recently shown that gamma irradiation reduces BrdU labeling (Tada et al., 2000; Snyder et al., 2001 ).”
• Radiation-induced brain injury: A review (2012, background): “, 1996), decreased proliferation of the surviving NSC, and decreased NSC differentiation into neurons (Snyder et al., 2001; Monje et al., 2002; Mizumatsu et al., 2003).”
• Inhibition of neurogenesis interferes with hippocampus‐dependent memory function (2006, methodology): “…the same irradiation procedure, we have shown that the procedure had no effects on synaptic transmission or long-term potentiation attributed to the mature neurons in DG, but caused a selective reduction of the plasticity due to the immature neurons (Snyder et al., 2001, 2005, Wang et al., 2005).”
• Structural Plasticity and Hippocampal Function (2010, background): “…immature neurons exhibit depolarization by GABA, enhanced excitability, low LTPinduction threshold, and more robust LTP that unlike mature granule cells is insensitive to GABA inhibition (Ge et al. 2006, 2007; Karten et al. 2006; Schmidt-Hieber et al. 2004; Snyder et al. 2001; Wang et al. 2000).”
• A model of hippocampal neurogenesis in memory and mood disorders. (2007, background): “These functions become compromised in depression and, when restored, can contribute indirectly to recovery from depression, as outlined later in this article.”
• Hippocampal neurogenesis: regulation by stress and antidepressants. (2006, background): “Some have estimated that immature neurons comprise as much as 5%–10% of the total cellular population of the dentate gyrus in rodents (Snyder et al 2001).”
• A putative role for neurogenesis in neuro-computational terms: inferences from a hippocampal model. (2009, neutral): “New neurons are known to have special characteristics through which they are thought to have an important role in dentate gyrus plasticity (Snyder et al., 2001).”
• Anatomical gradients of adult neurogenesis and activity: young neurons in the ventral dentate gyrus are activated by water maze training (2009, positive): “There is considerable evidence that these adult-born granule neurons are physiologically functional (Wang et al., 2000; Snyder et al., 2001; van Praag et al., 2002; Esposito et al., 2005; Ge et al., 2006) and contribute to hippocampus-dependent behaviors (Shors et al., 2001, 2002; Santarelli et…”
• Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons (2008, background): “It was recently demonstrated that changes in adult neurogenesis correlate with changes in medial perforant path LTP in the absence, but not in the presence, of picrotoxi”
• Synaptic integration and plasticity of new neurons in the adult hippocampus (2008, result): “2B), a result consistent with previous field recordings (Snyder et al. 2001).”
• Hippocampal granule cells opt for early retirement (2010, background): “…enhanced excitability and plasticity that, depending on experimental paradigm, can be observed to occur from 2 weeks to 5 months (Wang et al., 2000; Snyder et al., 2001; van Praag et al., 2002; Ambrogini et al., 2004; Schmidt-Hieber et al., 2004; Esposito et al., 2005; Ramirez-Amaya, 2005; Song et…”