Hippocampal neurogenesis: regulation by stress and antidepressants.

By A. Dranovsky, R. Hen. Biological Psychiatry, 2006

691 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/b95ad51229832b9233312874dd4675cbae2b8258

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Hen
2. E. Nestler
3. R. Duman
4. G. Agam
5. R. Belmaker
6. H. Schmidt
7. L. Monteggia
8. Amar Sahay

In Developmental Neuroscience

1. R. Hen
2. E. Nestler
3. R. Duman
4. G. Agam
5. R. Belmaker
6. C. Greer
7. M. Whitman
8. A. Kriegstein

In Pharmacology

1. R. Duman
2. G. Agam
3. R. Belmaker
4. L. Monteggia
5. R. Hen
6. E. Nestler
7. H. Schmidt
8. William A. Carlezon

Citations in the corpus

• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “…and somatic antidepressant treatments increase adult hippocampal neurogenesis as well as expression of neurotrophic factors in the hippocampus, which suggests that these effects may reverse or block the effects of stress on hippocampal atrophy (Dranovsky and Hen, 2006; Duman and Monteggia, 2006).”
• Major depressive disorder. (2008, positive): “The neocortex and hippocampus also appear to play critical roles in the symptoms related to the cognitive deficits that are prevalent in depressed patients [55], and the nucleus accumbens and amygdala seem to be core regions for anhedonia and emotional memory-related”
• Adult hippocampal neurogenesis in depression (2007, background): “Adult hippocampal neurogenesis and etiology of depression The possibility that adult-born neurons are required for some of the behavioral effects of antidepressants and the well documented deleterious effects of stress on adult hippocampal neurogenesis has fueled investigation into whether impair”
• A neurotrophic model for stress-related mood disorders. (2006, background): “w alberg J, Eisch AJ, Nestler EJ, Duman RS (2000): Chronic antidepressant treatment increases neurogenesis in adult hippocampus.”
• Experience dictates stem cell fate in the adult hippocampus. (2011, positive): “…blocks neurogenesis and disrupts the neurogenic niche (Monje et al., 2002; Santarelli et al., 2003), while exercise with environmental enrichment (EEE) potently stimulates neurogenesis (Doetsch and Hen, 2005; Dranovsky and Hen, 2006; Ming and Song, 2005; van Praag et al., 1999; Zhao et al., 2008).”
• Antidepressants increase neural progenitor cells in the human hippocampus (2009, background): “In rodents, stress decreases neurogenesis while antidepressants (Dranovsky and Hen 2006), environmental enrichment, exercise (Kempermann et al, 1998; van Praag et al, 1999) and learning (Leuner et al, 2004) stimulate neurogenesis.”
• Depression: An Evolutionarily Conserved Mechanism to Terminate Separation Distress? A Review of Aminergic, Peptidergic, and Neural Network Perspectives (2009, background): “…Cipriani, Balgkouranidou, & Scattoni, 2006), one of the candidate mechanisms that may contribute to pharmacological antidepressant effects (Dranovsky & Hen, 2006; Jacobs, Praag, & Gage, 2000), and REM disruption indeed may account for the efficacy of anticholinergic drugs and some SSRIs…”
• Adult neurogenesis and the olfactory system. (2009, background): “In fact, a variety of antidepressant treatments, including multiple classes of medications and electroconvulsive therapy, increase hippocampal neurogenesis, leading to the hypothesis that clinical depression may be a disorder of neurogenesis (Malberg et al., 2000; Duman, 2004; Dranovsky and Hen, 200”
• Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms (2008, background): “Many different forms of acute and chronic stress have been shown to reduce neurogenesis in the rodent hippocampus (reviewed in Duman, 2004; Dranovsky and Hen, 2006).”
• The mesolimbic dopamine reward circuit in depression. (2006, background): “…where its induction by antidepressant treatments seems to be important for their behavioral activity (Duman et al 1997; Monteggia et al 2004; Duman and Monteggia 2006; but see Conti et al 2002, who show that CREB is important for BDNF expression in hippocampus but that neither is necessary…”
• The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “New neurons in the adult dentate gyrus have been implicated in learning and memory (Shors et al. 2002, Zhao et al. 2008), and aberrant neurogenesis in this brain region has been linked to depression (Dranovsky & Hen 2006), neuroinflammation (Monje et al. 2003), and epilepsy (Parent et al. 2006).”