Synaptic integration and plasticity of new neurons in the adult hippocampus

By S. Ge, Kurt Sailor, Guo-li Ming, Hongjun Song. 2008

237 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience

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Citations in the corpus

Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus (2010, background): “This suggests that young neurons may selectively undergo LTP when mature neurons do not, such as when they are subject to the strong inhibition characteristic of the DG both in vitro and in vivo (Dudek et al., 1976; Wigstrom and Gustafsson, 1983; Snyder et al., 2001; Ge et al., 2008).”
Modification of hippocampal circuitry by adult neurogenesis (2012, background): “…supports the notion that newborn neurons do not merely replace lost neu- rons in the adult hippocampus; but are rather part of a continuously ongoing process that sculpt the existing neuronal circuitry of the adult brain as it responds to experiences encountered throughout life (Ge et al., 2008).”
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease (2009, unknown): “, 2005) and dendritic growth of newborn GCs in the adult brain (Ge et al., 2008).”
Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases (2013, background): “Early excitatory GABAergic input critically regulates the survival and maturation of adult-born hippocampal neurons (Ge et al., 2006, 2008).”
Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later (2015, background): “In both neurogenic niches, adult NSCs primarily generate new neurons, which are hyper-excitable and exhibit a lower threshold for long-term potentiation induction during a critical period when compared to mature neurons (Ge et al., 2008).”
Krüppel-Like Factor 9 Is Necessary for Late-Phase Neuronal Maturation in the Developing Dentate Gyrus and during Adult Hippocampal Neurogenesis (2009, background): “Several lines of evidence suggest that 4- to 6-week-old neurons are substrates for ACSF-LTP (Bergami et al., 2008; Ge et al., 2008).”
Input-specific GABAergic signaling to newborn neurons in adult dentate gyrus (2009, background): “In the dentate gyrus, neural progenitors proliferate and differentiate into newborn neurons that undergo a protracted maturational period culminating in full integration in the hippocampal network (Ge et al., 2008).”
Adult neurogenesis and the plasticity of the dentate gyrus network (2011, unknown): “2; Ge et al., 2007, 2008).”
DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 (2009, unknown): “Newborn dentate granule cells become integrated into the hippocampal neuronal circuitry through a stereotypic process, including neuronal morphogenesis, migration, axon/dendritic growth, and synapse formation (Duan et al., 2008; Ge et al., 2008).”
Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network (2012, unknown): “One previous observation suggested that, when GABAergic inhibition is intact, LTP is more robust in young neurons (21).”