In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog

By Sohyun Ahn, A. Joyner. 2005

731 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

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In Developmental Neuroscience

In Molecular Biology

Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Shh signaling is also activated in radial glia-like cells (Ahn and Joyner, 2005) and required for their establishment and maintenance in the adult SVZ and SGZ (Balordi and Fishell, 2007; Han et al., 2008).”
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains (2010, background): “Slowly diving adult neural stem cells and transit-amplifying cells respond to Shh, but these Shh-sensitive cells seem to appear after late embryonic periods (Ahn and Joyner, 2005).”
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain (2008, background): “Labeled granule cells gradually increased in number and expanded into the granular cell layer, mostly in its inner side, as previously describe”
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “…to maintain neural stem cells in the forebrain subventricular zone, but it is unclear exactly what cells are producing Hedgehog, whether they are a specialized niche component, or whether expression is generalized throughout the subventricular zone (Ahn and Joyner, 2005; Balordi and Fishell, 2007).”
Medulloblastoma can be Initiated by Deletion of patched in Lineage-Restricted Progenitors or Stem Cells (2008, positive): “Ptc is an antagonist of the Sonic hedgehog (Shh) signaling pathway, which functions as a critical regulator of both stem cells and progenitors in the central nervous system (Ahn and Joyner, 2005; Balordi and Fishell, 2007;Wechsler-Reya and Scott, 1999).”
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons (2007, background): “Because the Hh-mediated removal of the Gli3 repressor can occur in the absence of expression of Gli1 (Rallu et al., 2002), if Hh were acting in this manner in A cells, the absence of Gli1 expression in this population would not be surprising.”
High Levels of Id1 Expression Define B1 Type Adult Neural Stem Cells (2009, background): “Retroviral, adenoviral, and genetic lineage-tracing experiments showed that at least some of the subventricular astrocytes, the B1 type astrocytes, continue to divide and produce cells that eventually differentiate into neurons and glia (Ahn and Joyner, 2005; Doetsch et al., 1999a; Merkle et al., 20”
A Specialized Vascular Niche for Adult Neural Stem Cells (2008, background): “Within the adult SVZ, a subset of glial fibrillary acidic protein (GFAP)-expressing astrocytes (type B cells) are stem cells (Ahn and Joyner, 2005; Doetsch et al., 1999a; Garcia et al., 2004; Imura et al., 2003; Laywell et al., 2000; Sanai et al., 2004).”
Experience dictates stem cell fate in the adult hippocampus. (2011, neutral): “Some indelible lineage studies have been carried out looking at the adult hippocampus (Ahn and Joyner, 2005; Imayoshi et al., 2008; Lagace et al., 2007; Li et al., 2008).”
Centrioles, centrosomes, and cilia in health and disease. (2009, background): “It is also important in adult tissues, as it can promote the proliferation of adult stem cells (Ahn and Joyner, 2005) and is one of the most frequently upregulated signaling pathways in human cancers (Jiang and Hui, 2008).”
Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “Oligodendrocytes can also be generated in the adult SVZ both under normal conditions (Ahn & Joyner 2005) and after demyelination (Nait-Oumesmar et al. 1999; Picard-Riera et al. 2002), but the cell type that generates them remains undefined.”
Development of neural stem cell in the adult brain. (2008, background): “Hedgehog signaling is activated in quiescent adult NSCs [21] and appears to be required for both establishment and maintenance of proper NSC pools in the adult SVZ and SGZ [22,23].”
Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma (2007, background): “We investigated the role of the Hedgehog (Hh) pathway in malignant gliomas, as it plays an essential role in cerebellar precursor cells [6–8], in growth of the cerebral cortex [9], and in neural stem cells in the adult brain [ 10 ].”