Cyclopamine‐Mediated Hedgehog Pathway Inhibition Depletes Stem‐Like Cancer Cells in Glioblastoma

By Eli E. Bar, Aneeka Chaudhry, Alex Lin, Xing Fan, K. Schreck, W. Matsui, S. Piccirillo, Angelo Luigi Vescovi, F. DiMeco, A. Olivi and 1 more. Stem Cells, 2007

630 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/6e194ef9620a424f697d738febdd308eff040d53

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In Genetics

1. Jeremy N. Rich
2. J. Lathia
3. Anita B. Hjelmeland

In Molecular Biology

1. G. Fishell
2. Jeremy N. Rich
3. D. Rowitch

Citations in the corpus

• Integrin alpha 6 regulates glioblastoma stem cells (2010, background): “GSCs activate a number of key stem cell signaling pathways, including Akt, bone morphogenetic protein, c-myc, hypoxia response, Notch, and Sonic Hedgehog (Bar et al., 2007; Eyler et al., 2008; Fan et al., 2006; Li et al., 2009; Piccirillo et al., 2006; Wang et al., 2008b).”
• Medulloblastoma can be Initiated by Deletion of patched in Lineage-Restricted Progenitors or Stem Cells (2008, positive): “, 2007) and that treatment with Shh pathway inhibitors can suppress the growth of glioma cell lines and xenografts (Bar et al., 2007; Clement et al., 2007).”
• Cancer stem cells in glioblastoma (2015, background): “Gliomas contain primary cilia, and the resulting CSCs are dependent on hedgehog signaling (Bar et al. 2007; Clement et al. 2007; Ehtesham et al. 2007).”