Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons

By F. Balordi, G. Fishell. 2007

179 citations recorded by the source corpus.

We examined the postnatal consequences of removing Hedgehog signaling within the adult stem cell niche. Although at birth the subventricular zone appears normal in mice lacking Hedgehog signaling, by postnatal day 8 it is greatly impaired, and cell death is increased. In addition, both the quiescent B stem cell population and transit-amplifying C cells become depleted postnatally. In contrast, the A cell population expands precociously, mostly fails to migrate to the olfactory bulbs, and is ultimately also depleted by postnatal day 30. In vitro and in vivo analyses demonstrate that this failure in migration is a result of nonautonomous signaling, possibly caused by a reduction in Slit1 ligand in A cells. These results suggest that Hedgehog signaling is required for the maintenance of the B and C cell populations and indirectly for the migration of the neurons that are generated from the adult stem cell niche.

Subfields: Developmental Neuroscience, Molecular Biology

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Shh signaling is also activated in radial glia-like cells (Ahn and Joyner, 2005) and required for their establishment and maintenance in the adult SVZ and SGZ (Balordi and Fishell, 2007; Han et al., 2008).”
Hedgehog Signaling in Development and Cancer (2008, unknown): “The Hh pathway has been extensively analyzed in neural stem and progenitor cells (Ahn and Joyner, 2005; Balordi and Fishell, 2007; Dahmane et al., 2001; Lai et al., 2003; Machold et al., 2003; Palma et al., 2005; Wechsler-Reya and Scott, 1999).”
Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. (2008, background): “…to maintain neural stem cells in the forebrain subventricular zone, but it is unclear exactly what cells are producing Hedgehog, whether they are a specialized niche component, or whether expression is generalized throughout the subventricular zone (Ahn and Joyner, 2005; Balordi and Fishell, 2007).”
Medulloblastoma can be Initiated by Deletion of patched in Lineage-Restricted Progenitors or Stem Cells (2008, unknown): “Ptc is an antagonist of the Sonic hedgehog (Shh) signaling pathway, which functions as a critical regulator of both stem cells and progenitors in the central nervous system (Ahn and Joyner, 2005; Balordi and Fishell, 2007;Wechsler-Reya and Scott, 1999).”
Leptin Receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow (2014, unknown): “We did not detect any EYFP+ CFU-F colonies formed by bone marrow cells from Nestin-creER; loxp-EYFP mice (Figure 2A).”
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains (2010, background): “…of neuroblasts in the absence of Smoothened, an essential effector of Shh, although expansion of Mash1 type C cells was not observed, suggesting that Shh signaling regulates both maintenance of type B cells and proliferation of type C cells (Machold et al., 2003; Balordi and Fishell, 2007a,b).”
Development of neural stem cell in the adult brain. (2008, background): “Maintenance, proliferation, and fate specification of adult neural stem cells Continuous neurogenesis in the SVZ and SGZ throughout life suggests a sustained maintenance of adult NSCs. Hedgehog signaling is activated in quiescent adult NSCs [21] and appears to be required for both establishment and ”
Mechanisms of stem cell self-renewal. (2009, background): “Hedgehog signaling is required not only for normal neural stem cell maintenance, but also for brain tumor cell proliferation (Balordi & Fishell 2007, Ruiz i Altaba et al. 2002).”