Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain

By Itaru Imayoshi, Masayuki Sakamoto, T. Ohtsuka, K. Takao, T. Miyakawa, Masahiro Yamaguchi, K. Mori, T. Ikeda, S. Itohara, Ryoichiro Kageyama. 2008

1,067 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

In Developmental Neuroscience

Citations in the corpus

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory? (2010, background): “However, many studies showed impairments in the long-term but not the short-term retention of spatial memory as a consequence of reduced adult neurogenesi”
Dynamics of hippocampal neurogenesis in adult humans (2013, positive): “Although it is known that adult-born neurons integrate long term in rodents, whether they last for the remainder of the animal’s life has not been studied, although the available data are compatible with a preferential loss of adult-born neurons (Imayoshi et al., 2008; Kempermann et al., 2003; Ninko”
Effect of ablated hippocampal neurogenesis on the formation and extinction of contextual fear memory (2009, background): “In contrast, some reports indicate that ablation of hippocampal neurogenesis has no effect on learning, even in hippocampus-dependent memory tasks such as the contextual fear memory task and the Morris water maze task (Table 1) [3-6,8,9].”
FoxO3 regulates neural stem cell homeostasis (2009, positive): “In the adult brain, the generation of new neurons (neurogenesis) from NSCs is thought to play an important role in learning and memory, spatial pattern separation, and odor discrimination (Clelland et al., 2009; Gheusi et al., 2000; Imayoshi et al., 2008).”
Adult neurogenesis and the olfactory system. (2009, background): “Ablating neurogenesis impairs spatial memory and contextual fear conditioning (Saxe et al., 2006; Imayoshi et al., 2008), but actually improved performance on some working memory tasks (Saxe et al.”
Adult-born neurons facilitate olfactory bulb pattern separation during task engagement (2018, neutral): “However, other studies have found little effects of ABN manipulation on odor discrimination (Breton-Provencher et al., 2009; Imayoshi et al., 2008; Lazarini et al., 2009).”
Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding (2016, positive): “In both rodents and humans, a significant fraction of DG neurons are replaced by neurons generated in adulthood (Imayoshi et al., 2008; Spalding et al., 2013).”
Disruption of Adult Neurogenesis in the Olfactory Bulb Affects Social Interaction but not Maternal Behavior (2010, neutral): “…or blocking olfactory neurogenesis affects behavior in a task-dependent manner: while olfactory discrimination ability seems to be unaffected (Imayoshi et al., 2008; Breton-Provencher et al., 2009; Lazarini et al., 2009), deficits in either long or short-term odor memory have been reported…”
Interneurons Produced in Adulthood Are Required for the Normal Functioning of the Olfactory Bulb Network and for the Execution of Selected Olfactory Behaviors (2009, methodology): “Surprisingly, however, genetic ablation of adult bulbar neurogenesis did not affect olfactory discrimination and long-term odor-associative memory (Imayoshi et al., 2008).”
Adult-born hippocampal neurons are more numerous, faster-maturing and more involved in behavior in rats than in mice (2009, background): “much longer than in rat studies (Saxe et al., 2006; Saxe et al., 2007; Imayoshi et al., 2008).”
Pattern separation: a common function for new neurons in hippocampus and olfactory bulb (2011, neutral): “, 2000), most manipulations of adult neurogenesis (Breton-Provencher et al., 2009; Imayoshi et al., 2008; Lazarini et al., 2009; Valley et al., 2009) have not found impairments in olfactory discrimination.”
Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains (2010, background): “Although our Nes-CreER T2 mice efficiently induce recombination in ependymal cells after tamoxifen treatment (Imayoshi et al., 2008b), almost all ependymal cells (S100 ) were negative for Ki67, a marker for proliferating cells, in Rbpj-conditional knockout mice, indicating that very few ependymal…”
Is adult neurogenesis essential for olfaction? (2011, neutral): “3 Imayoshi, I et al. (2008) Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.”
Dopaminergic Modulation of Cortical Inputs during Maturation of Adult-born Dentate Granule Cells (2011, background): “…make an impact on hippocampal function, which has been suggested by a strong correlation between adult neurogenesis and performance in hippocampusdependent learning tasks (Shors et al., 2001; Saxe et al., 2006; Dupret et al., 2008; Imayoshi et al., 2008; Zhang et al., 2008; Clelland et al., 2009).”
Experience dictates stem cell fate in the adult hippocampus. (2011, neutral): “Some indelible lineage studies have been carried out looking at the adult hippocampus (Ahn and Joyner, 2005; Imayoshi et al., 2008; Lagace et al., 2007; Li et al., 2008).”
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease (2009, background): “Ablation of neurogenesis impairs some aspects of learning and memory (Imayoshi et al., 2008; Saxe et al., 2006; Snyder et al., 2005b).”