Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis.

By S. Schoppmann, P. Birner, J. Stöckl, R. Kalt, R. Ullrich, Carola Caucig, E. Kriehuber, K. Nagy, K. Alitalo, D. Kerjaschki. American Journal of Pathology, 2002

818 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/24cb2b9b9ca5d6d21258568aae526275b0e6d153

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. A. Mantovani
2. A. Sica
3. H. Wiig
4. J. Pollard
5. P. Allavena
6. M. Swartz
7. K. Alitalo
8. T. Tammela

In Oncology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. J. Pollard
5. C. Garlanda
6. H. Wiig
7. G. Solinas
8. G. Germano

In Surgery

1. K. Alitalo
2. M. Swartz
3. A. Mantovani
4. J. Pollard
5. C. Garlanda

Citations in the corpus

• Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “Lymphatic endothelial growth factors secreted by TAM are related to peritumoral lymphangiogenesis [95, 96].”
• Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C–dependent buffering mechanism (2009, background): “MPS cell participation in the development of hypertension-induced target organ damage, and their influence on lymphangiogenesi”
• Role of tumor-associated macrophages in tumor progression and invasion (2006, background): “In human cervical cancer, VEGF-C production by TAMs was proposed to play a role in peritumoral lymphoangiogenesis and subsequent dissemination of cancer cells with formation of lymphatic metastasis [54].”
• Distinct role of macrophages in different tumor microenvironments. (2006, background): “may also promote dissemination of tumor cells by stimulating the formation of lymphatic vessels in tumors (54).”
• The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance (2008, background): “More recently, VEGF-A, a chemotactic factor for monocytes, was shown to increase lymphoangiogenesis via the recruitment of circulating monocytes (16).”
• VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. (2004, background): “cytes also strongly expresses VEGF-C and VEGF-D upon recruitment to peritumoral sites or in vitro stimulation (8).”
• Macrophages in Tumor Microenvironments and the Progression of Tumors (2012, background): “In human cervical cancer, the VEGF-C released by TAMs plays a novel role in peritumoral lymphangiogenesis and the subsequent formation of lymphatic metastases [54].”
• Inflammation and cancer (2002, neutral): “16 ), TAMs produce a number of potent angiogenic and lymphangiogenic growth factors, cytokines and proteases, all of which are mediators that potentiate neoplastic progressio”