VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment.

By C. Cursiefen, Lu Chen, L. P. Borges, D. Jackson, Jingtai Cao, C. Radziejewski, P. D’Amore, M. Dana, S. Wiegand, J. Streilein. Journal of Clinical Investigation, 2004

1,076 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/471a10f7149aedd7b5680c2e4e7fa48431eeccca

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In Molecular Biology

1. K. Alitalo
2. Peter Carmeliet
3. A. Sica
4. P. Allavena
5. T. Tammela
6. D. Collen
7. A. Mantovani
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In Oncology

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3. P. Allavena
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In Surgery

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Citations in the corpus

• Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vessels. (2007, methodology): “Signals were detected using fluorescently conjugated secondary antibodies (Alexa 488 or 546, Molecular Probes) or peroxidase-labeled IgGs (Dako) followed by tyramide signal amplification (Perkin Elmer, Life Sciences).”
• Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. (2005, neutral): “More recent studies show that lymphangiogenesis can be stimulated or inhibited by agonists or antagonists of VEGFR-3 signaling independent of angiogenesis (32, 33).”
• Lymphangiogenesis in development and human disease (2005, background): “At least some of the effects of VEGF-A on lymphatic vessels may be secondary to the induction of vascular hyperpermeability and to the recruitment of the inflammatory cells that produce VEGF-C and VEGF-”
• The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance (2008, background): “A variety of chemokines, including CCL2, CXCL12, CXCL8, CXCL1, CXCL13, CCL5 (57), CCL17, and CCL22, have been detected in neoplastic tissues as products of either tumor cells or stromal elements.”
• Lymphoid organ development: from ontogeny to neogenesis (2006, background): “Lymphatic vessels have also been noted in murine models of corneal transplantation, suture-induced corneal inflammation and Mycoplasma pulmonis –induced airway inflammatio”
• Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “It has been shown that VEGF-A increases lymphangiogenesis via recruitment of monocytes [97].”
• Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves (2015, background): “VEGF-A has been described to play a role in the recruitment of macrophages from the bloodstream (Cursiefen et al., 2004).”