Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis

By H. Flint, E. Bayer, M. Rincón, R. Lamed, Bryan A. White. Nature Reviews Microbiology, 2008

1,664 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/23ed522bacfaa443aec899fd4c35235814006f62

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Citations in the corpus

Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon (2012, background): “The starch-utilization system of B. thetaiotaomicron has been studied extensively and is thought to represent a sequestration system that is particularly suited to the utilization of soluble starch molecules (Flint et al., 2008).”
Gut microbiome, obesity, and metabolic dysfunction. (2011, background): “indigestible common polysaccharides in the diet (36) via enzymes such as glycoside hydrolases and others that are not encoded with-”
The role of pH in determining the species composition of the human colonic microbiota. (2009, neutral): “Bacteroides spp. possess sophisticated systems for soluble polysaccharide utilization, which apparently allow them to compete very effectively for these substrates in the mixed community at near neutral pH (Salyers et al., 1977; Flint et al., 2008).”
The core gut microbiome, energy balance and obesity (2009, background): “The gut microbiome encodes metabolic capacities that remain largely unexplored but include the degradation of otherwise indigestible components of our diet (Backhed et al. 2005; Sonnenburg et al. 2005; Flint et al. 2008).”
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41) (2011, background): “Under a fed condition, mammals use glucose as the main metabolic fuel, and short-chain fatty acids (SCFAs) produced by the colonic bacterial fermentation of dietary fiber also contribute a significant proportion of the daily energy requirement (7, 8).”
Specificity of polysaccharide use in intestinal Bacteroides species determines diet-induced microbiota alterations (2010, neutral): “Many complex plant polysaccharides in the human diet are resistant to host-mediated degradation due to either insolubility or lack of human-encoded hydrolytic enzymes (Flint et al., 2008; Louis et al., 2007; Sonnenburg et al., 2005).”
Composition, Diversity, and Origin of the Bacterial Community in Grass Carp Intestine (2012, background): “Among its many important functions, the gut microbiota can convert feedstuffs into microbial biomass and fermentation end products that can be utilized by the animal host [4,5].”
Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41 (2008, background): “Our proteome has a very limited repertoire of glycoside hydrolases needed to digest complex dietary plant polysaccharides: the microbiota synthesizes a large arsenal of these enzymes (2), and allows us to process complex dietary carbohydrates to short-chain fatty acids (SCFAs), principally acetate, ”
Fibrolytic Rumen Bacteria: Their Ecology and Functions (2009, neutral): “flavefaciens FD1 possesses at least 65 genes encoding glycoside hydrolases (Flint et al., 2008).”
Resistant Starches Types 2 and 4 Have Differential Effects on the Composition of the Fecal Microbiota in Human Subjects (2010, background): “) present in the human GIT can utilize this substrate in vitro, and various bacterial systems involved in the degradation of starch have been identified by genomic approaches [6,34,36,37,38,39,40,41,42,43].”
Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts (2011, background): “The microbial symbionts that occupy this habitat produce an arsenal of enzymes that degrade dietary complex carbohydrates (glycans) that cannot be hydrolyzed by host enzymes [1].”