Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts

By Eric C. Martens, Elisabeth C. Lowe, Herbert C. Chiang, Nicholas A. Pudlo, Meng Wu, N. McNulty, D. W. Abbott, Bernard Henrissat, Harry J. Gilbert, D. N. Bolam and 1 more. PLoS Biology, 2011

817 citations recorded by the source corpus.

Competition for nutrients contained in diverse types of plant cell wall-associated polysaccharides may explain the evolution of substrate-specific catabolic gene modules in common bacterial members of the human gut microbiota.

Subfields: Food Science, Plant Science

View Paper: https://www.semanticscholar.org/paper/ceff3275255357de59e6ae2096baad20e5927438

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Food Science

1. Jianbo Xiao
2. N. Moran
3. H. Holscher
4. F. Bäckhed
5. E. Martens
6. Philipp Engel

In Plant Science

1. N. Moran
2. Philipp Engel

Citations in the corpus

• The Reciprocal Interactions between Polyphenols and Gut Microbiota and Effects on Bioaccessibility (2016, background): “Higher bioavailability of phenolic compounds, and the resultant beneficial health effects as determined by the consumption of whole grains, vegetables and fruits, can be related to the end-products of microbial metabolism forming short-chain fatty acids such as butyrate, and phenolic acids such as p”
• Target highlights from the first post-PSI CASP experiment (CASP12, May–August 2016) (2017, neutral): “with RG-I as the sole carbon source are directly involved in its metabolism.(72,73) The organism is capable of cleaving 20 out of the 21 unique glycosidic linkages in RG-II and biochemical evidence suggests that the CASP12 target T0912 (BT1002) is one of 7 novel enzymes recruited by B.”
• A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility (2016, neutral): “To provide an additional layer of functional knowledge about complex carbohydrate metabolism, we pre-evaluated our 14 species for growth in vitro on a panel of 42 plant- and animalderived mono- and polysaccharides, including purified mucin O-glycans (MOGs) as sole carbon sources (Martens et al., 201”
• Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates (2014, neutral): “Residents of the microbiota are equipped with a specialized collection of enzymes such as glycoside hydrolases and polysaccharide lyases, which can break down complex carbohydrate linkages into consumable oligosaccharides or monosaccharides (Cantarel et al., 2009; Martens et al., 2011).”
• Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella. (2015, background): “, 2003), it lacks essential genes for degradation of complex polysaccharides compared to other Bacteroides strains (Dodd et al., 2010; Martens et al., 2011).”
• Dietary fiber and prebiotics and the gastrointestinal microbiota (2017, background): “In general, the more complex the polysaccharide, the more glycosidase are necessary to metabolize it.(50) Some bacteria possess many different enzymes that allow them to metabolize dozens of different complex carbohydrates, while other microbes are only able to utilize one or a few different polysac”
• Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease (2012, neutral): “coli [65,66].”
• Functional diversity within the simple gut microbiota of the honey bee (2012, background): “Alternatively, as in other microbial gut communities (19, 20), this diversity might confer fitness benefits to bees when facing environmental challenges such as exposure to pathogens, varying food sources, or toxic compounds.”