Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon

By X. Ze, S. Duncan, P. Louis, H. Flint. The ISME Journal, 2012

976 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/3f15deffeac8a0427ad17b35cc6ebe16e95541d9

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Citations in the corpus

Short chain fatty acids in human gut and metabolic health. (2020, positive): “…bromii, Eubacterium rectale, B. adolescentis and Prevotella species contributed to starch degradation , and R. bromii has been identified as a keystone starch degrader, releasing oligo-and mono-saccharides that can be used by other bacteria for growth by cross-feeding (Ze et al. , 2012).”
The Influence of Probiotics on the Firmicutes/Bacteroidetes Ratio in the Treatment of Obesity and Inflammatory Bowel disease (2020, neutral): “thetaiotaomicron, and Bifidobacterium adolescentis [37].”
Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications (2019, background): “For example, Ruminococcus bromii can degrade resistant starches, and several species can utilize the fermentation products of this reaction [31].”
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism (2016, background): “Fermentation of resistant starch is thought to contribute significantly to butyrate production in the colon and is dominated by Ruminococcus bromii, such that absence of the organism significantly reduces resistant starch fermentation.(15) A surprisingly small number of organisms, dominated by Faeca”
Dynamics of Human Gut Microbiota and Short-Chain Fatty Acids in Response to Dietary Interventions with Three Fermentable Fibers (2018, background): “bromii was the dominant responder (22, 36) and was therefore”
The severity of NAFLD is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota (2016, background): “Ruminococcus are able to ferment complex carbohydrates, such as cellulose, pectine, resistant starch,((44,45)) and are acetate and propionate producers.”
Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3 (2020, background): “Ruminococcus bromii is a common gut microbe that is surprisingly understudied due to its fastidious anaerobicity and general non-pathogenicity (Ze et al., 2012) but it is prevalent in over half of typical gut microbiomes.”
Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella. (2015, background): “Members of the Actinobacteria and Firmicutes phyla have been suggested to include species that are primary degraders of complex carbohydrates (Flint et al., 2012; El Kaoutari et al., 2013; Leitch et al., 2007; Ze et al., 2012), suggesting that Prevotella and Bacteroides may compete with those specie”
Microbiota metabolite short chain fatty acids, GCPR, and inflammatory bowel diseases (2016, background): “Fermentation of resistant starch greatly contributes to butyrate production in the colon, which is dominated by Ruminococcus bromii [27].”
Ecology and exploration of the rare biosphere (2015, background): “Keystone species have a disproportion ately large effect on their environment relative to their abundance, often serving as gatekeepers to ecosystem functions, as is the case for specialist degraders 88 .”