Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

By I. Kimura, Daisuke Inoue, Takeshi Maeda, Takafumi Hara, A. Ichimura, Satoshi Miyauchi, Makio Kobayashi, A. Hirasawa, G. Tsujimoto. Proceedings of the National Academy of Sciences of the United States of America, 2011

987 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Physiology

View Paper: https://www.semanticscholar.org/paper/d7d87ee7530bc42e428c0fbc074d257f68232b11

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In Endocrine and Autonomic Systems

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Citations in the corpus

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human (2012, background): “Furthermore, the expression of Scd1 and several adipogenic genes 14,19 ( Pparg , Fabp4 and Srebf1 ) was suppressed in mouse embryonic fibroblast (MEF)-derived adipocytes from GPR120-deficient mice, indicating that GPR120 is required for normal adipogenesis, as previously reported in differentiating…”
Fecal microbiota transplantation and emerging applications (2012, background): “Furthermore, the gut microbiota is involved in multiple elements of energy metabolism, including energy harvest, metabolic rate and energy storage”
Dietary Gut Microbial Metabolites, Short-chain Fatty Acids, and Host Metabolic Regulation (2015, background): “FFAR3 is abundantly expressed in sympathetic ganglia as well [45].”
Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation (2013, background): “These effects are mediated via SCFA signaling through the G protein-coupled receptors Gpr41 and 43, which are expressed in adipocytes, neutrophils, and sympathetic ganglia (13).”
Short‐chain fatty acids: microbial metabolites that alleviate stress‐induced brain–gut axis alterations (2018, background): “The sympathetic nervous system could play a key role in the mechanisms involved, as FFAR2 is expressed on autonomic and somatic sensory ganglia and activation hereof results in sympathetic nervous system activation (Kimura et al. 2011; Nohr et al. 2015), even though more research is warranted to val”
Butyrate: A Double-Edged Sword for Health? (2018, background): “…cell precursors, hematopoiesis of dendritic cells from bone marrow De Vadder et al., 2014 (36); Nøhr et al., 2013 (42); Trompette et al., 2014 (38); Kimura et al., 2011 (39) GPR43/FFAR2 Formate, acetate, propionate, butyrate, and pentanoate Adipocytes, skeletal muscle, heart, spleen, fetal…”
Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, background): “In particular, SCFAs are able to stimulate sympathetic nervous system (243), activate mucosal serotonin release (178), and alter memory and learning processes (443).”
Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota (2023, background): “Moreover, the action of those two receptors may influence the energy consumption of neurons [30], insulin secretion from Langerhans islets beta cells [31,32] and enteroendocrine function [33,34].”
The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems (2015, background): “One of the main product of bacterial metabolism are short-chain fatty acid (SCFAs), such as butyric acid, propionic acid and acetic acid, that are able to stimulate sympathetic nervous system [49], mucosal serotonin release [50] and to influence memory and learning process [51,52].”
Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults (2014, background): “46 Furthermore, SCFA activation of FFAR2 has been shown to reduce the sensitivity of murine adipocytes to insulin, leading to reduced lipid clearance by adipocytes and to increased energy expenditure, with preferential oxidation of lipid.”