Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

By B. Samuel, Abdullah Shaito, T. Motoike, F. Rey, Fredrik Bäckhed, J. Manchester, R. Hammer, S. Williams, J. Crowley, M. Yanagisawa and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2008

1,562 citations recorded by the source corpus.

Subfields: Gastroenterology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/471d144d253122b320d4ef2acb2bee941bc0efe2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. F. Bäckhed
5. S. Grenham
6. P. Kennedy
7. J. Foster

In Infectious Diseases

1. J. Cryan
2. Ted G. Dinan
3. F. Bäckhed
4. Jeremy K. Nicholson
5. G. Clarke
6. Jeffrey I. Gordon
7. Martin J. Blaser
8. Ilseung Cho

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. F. Bäckhed
5. Patrice D Cani
6. N. Delzenne
7. S. Grenham
8. Martin J. Blaser

Citations in the corpus

• Effects of Gut Microbes on Nutrient Absorption and Energy Regulation (2012, background): “It was speculated that the weight gain in the wild-type mice was due to an increased expression of the gut-derived hormone, peptide YY (PYY), which inhibits gut motility, thereby allowing more intestinal epithelial contact time in which to extract and absorb energy.(72,73) Although Gpr43 binding by ”
• Gut Microbiota in Cardiovascular Health and Disease (2017, background): “hormone PYY in gut epithelial L cells via GPR41, leading to increase in energy harvest from the diet.(102) By contrast, SCFAs”
• From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. (2016, neutral): “Furthermore, the microbiota, and presumably the resulting SCFAs, induced peptide YY (PYY) production in a GPR41-dependent fashion (Samuel et al., 2008).”
• The human gut microbiota: Metabolism and perspective in obesity (2018, background): “Butyrate produced by intestinal bacteria was present in smaller amounts in obese individuals(63) and regulated energetic homeostasis by stimulating adipocytes to produce leptin and by inducing GLP-1 secretion by L cells.(64) At least in mice, modulation of the gut microbiota by probiotics increased ”
• The Human Gut Microbiome – A Potential Controller of Wellness and Disease (2018, background): “…on a vast range of host physiological functions such as energy metabolism, appetite, as well as sympathetic nerve activity and immune response, potentially giving rise to interactive host-microbe signaling and gut-brain axis immune-inflammatory crosstalk (Xiong et al., 2004; Samuel et al., 2008).”
• Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41) (2011, background): “Recent studies, however, have reported that Gpr41 is not expressed in mouse adipose tissues (29-32).”
• Interactions between gut microbiota and host metabolism predisposing to obesity and diabetes. (2011, background): “(68) compared the effect of Gpr41 functional deletion on host adiposity and energy harvest from the diet in mice raised in germ-free conditions, conventionalized, or colonized with two prevalent human gut fermentative commensals, B.”