Retinoic acid imprints gut-homing specificity on T cells.

By M. Iwata, A. Hirakiyama, Yuko Eshima, H. Kagechika, Chieko Kato, Si‐Young Song. Immunity, 2004

1,608 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2303683920954a98c1a146cc4b857aa951aac957

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Citations in the corpus

Vitamin effects on the immune system: vitamins A and D take centre stage (2008, background): “In adult mammals, RALDH can be found in some gut-associated cells, including intestinal epithelial cells (IECs”
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses (2007, background): “32 ) and secrete the immunoregulatory cytokine IL-10, as well as retinoic acid, which can induce the mucosal homing of lymphocyte”
Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “In the gut, CD103+ DCs and stromal cells from Peyer’s patches and mesenteric LNs produce retinoic acid that triggers expression of α4β7 and CCR9 on T cells (182).”
Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing (2005, background): “Thus, the expression of retinoid dehydrogenase enzymes, catalyzing the sequential oxidation of vitamin A via retinal to retinoic acid appears in part to underlie their selective ability to generate gut-tropic T cells (13).”
TGF-beta: a master of all T cell trades. (2008, unknown): “that converts vitamin A to its metabolite retinoic acid (RA), the molecule responsible for the upregulation of gut-homing receptors on T cells (Iwata et al., 2004).”
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells (2009, background): “The active metabolite of vitamin D 3 , 1,25(OH) 2 D 3 , which is produced in the skin by the action of sunlight, 'imprints' a skin-homing phenotype in association with IL-12, whereas the active metabolite of dietary vitamin A produced in the gut 'imprints' a gut-homing phenotyp”
Translating innate immunity into immunological memory: implications for vaccine development. (2006, unknown): “Retinoic acid enhances the expression of a4b7 and CCR9 on T cells and imprints them with a gut tropism (Iwata et al., 2004).”
Oral tolerance (2011, background): “The importance of retinoic acid in the gut was first shown in studies, which demonstrated that DCs require retinoic acid to trigger the expression of gut-homing receptors such as aEb7 and CCR9 in T and B cells (14, 15).”