Vitamin effects on the immune system: vitamins A and D take centre stage
By J. Mora, M. Iwata, U. V. von Andrian. Nature reviews. Immunology, 2008
1,552 citations recorded by the source corpus.
Vitamins are essential constituents of our diet that have long been known to influence the immune system. Vitamins A and D have received particular attention in recent years as these vitamins have been shown to have an unexpected and crucial effect on the immune response. We present and discuss our current understanding of the essential roles of vitamins in modulating a broad range of immune processes, such as lymphocyte activation and proliferation, T-helper-cell differentiation, tissue-specific lymphocyte homing, the production of specific antibody isotypes and regulation of the immune response. Finally, we discuss the clinical potential of vitamin A and D metabolites for modulating tissue-specific immune responses and for preventing and/or treating inflammation and autoimmunity.
Subfields: Molecular Biology, Nutrition and Dietetics, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/1da02ae6be08815aa0bfd400c50e1c5dbc2e6ac7
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Citations in the corpus
- Molecular Mechanisms of Vitamin D Action (2012, neutral): “1) [7].”
- Role of the Microbiota in Immunity and inflammation (2014, background): “…could control unique aspects of the immune system is believed to be a highly generalizable observation extending to all micronutrients explored thus far, including iron, folate, zinc, selenium, and vitamins C, D, and E (Mora et al., 2008; Savy et al., 2009; von Essen et al., 2010).”
- Vitamin D and Immune Function (2013, background): “More recent studies confirmed additional direct effects of calcitriol on B cell homoeostasis, including inhibition of memory- and plasma-cell generation, as well as promotion of apoptosis of immunoglobulin-producing B cells [23,63,75].”
- The vitamin D3 axis in laryngeal cancer: a double-edged sword modulated by estrogen signaling (2025, unknown): “As an essential fat-soluble vitamin, vitamin D 3 participates in laryngeal cancer pathophysiology via two primary mechanisms: First, direct regulation of tumor cell biology, and second, modulation of the host immune microenvironment (22).”