Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing
By B. Johansson-Lindbom, M. Svensson, O. Pabst, C. Palmqvist, G. Marquez, R. Förster, W. Agace. Journal of Experimental Medicine, 2005
753 citations recorded by the source corpus.
Gut-associated lymphoid tissue (GALT) dendritic cells (DCs) display a unique ability to generate CCR9+ α 4 β 7 + gut-tropic CD8+ effector T cells. We demonstrate efficient induction of CCR9 and α 4 β 7 on CD8+ T cells in mesenteric lymph nodes (MLNs) after oral but not intraperitoneal (i.p.) antigen administration indicating differential targeting of DCs via the oral route. In vitro, lamina propria (LP)–derived DCs were more potent than MLN or Peyer's patch DCs in their ability to generate CCR9+ α 4 β 7 + CD8+ T cells. The integrin α chain CD103 (α E) was expressed on almost all LP DCs, a subset of MLN DCs, but on few splenic DCs. CD103+ MLN DCs were reduced in number in CCR7−/− mice and, although CD8+ T cells proliferated in the MLNs of CCR7−/− mice after i.p. but not oral antigen administration, they failed to express CCR9 and had reduced levels of α 4 β 7. Strikingly, although CD103+ and CD103− MLN DCs were equally potent at inducing CD8+ T cell proliferation and IFN-γ production, only CD103+ DCs were capable of generating gut-tropic CD8+ effector T cells in vitro. Collectively, these results demonstrate a unique function for LP-derived CD103+ MLN DCs in the generation of gut-tropic effector T cells.
Subfields: Immunology
View Paper: https://www.semanticscholar.org/paper/b6cb33a4233d3a58c5b9b99e84b46cdc0c19082c
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In Immunology
Citations in the corpus
- The Microbiome in Infectious Disease and Inflammation (2012, neutral): “In particular, a CD103 (also known as αE-integrin)-expressing DC population in the LP preferentially promotes the generation and homing of iTreg cells to the intestinal mucosa (222, 223, 239).”
- Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells (2010, background): “These CD103+ DCs were reported to migrate in the steady state from the LP to the MLNs, and displayed the unique ability to induce the expression of the gut-homing receptors CCR9 and 47 integrin on T cells in vitro (Annacker et al., 2005; Johansson-Lindbom et al., 2005).”
- Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions (2009, methodology): “…cells turn over rapidly in vivo (Jaensson et al., 2008), 9 h after injection JEM VOL. 206, December 21, 2009 Article 3105 CD103+ DCs are a migratory population of cells that continually migrate to the draining MLN (Johansson-Lindbom et al., 2005; Hammerschmidt et al., 2008; Jaensson et al., 2008).”
- Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. (2012, background): “In the intestinal lamina propria, CCR7-dependent migration to the mLNs has been shown to be specific feature of CD103 lamina propria DCs (Bogunovic et al., 2009; Coombes et al., 2007; Jaensson et al., 2008; Johansson-Lindbom et al., 2005; Schulz et al., 2009), whereas CCR7CX3CR1-GFP F4/80 resident m”