Farnesoid X receptor is essential for normal glucose homeostasis.

By Ke Ma, P. Saha, L. Chan, D. Moore. Journal of Clinical Investigation, 2006

845 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/222d50fae244f64b33293e8021d742e629ff1099

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. J. Y. Chiang
2. Tiangang Li
3. Johan Auwerx
4. P. Tontonoz
5. R. DePinho
6. David S. Wishart

In Molecular Biology

1. J. Y. Chiang
2. A. Calkin
3. P. Tontonoz
4. Tiangang Li
5. L. Rossetti
6. M. Matsumoto
7. Bart Staels
8. Johan Auwerx

In Oncology

1. J. Y. Chiang
2. Tiangang Li
3. P. Tontonoz
4. P. Edwards
5. Johan Auwerx
6. R. DePinho
7. A. Calkin
8. David S. Wishart

Citations in the corpus

• Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. (2007, background): “In this regard, residual HGP in Foxo1-deficient liver likely reflects the contribution of Foxo3 to this process, or that mediated by c/Ebpa (Wang et al., 1995), NR4 (Pei et al., 2006), STAT3 (Inoue et al., 2004), Fxr (Ma et al., 2006), and Foxa2 (Zhang et al., 2005).”
• Role of bile acids and bile acid receptors in metabolic regulation. (2009, background): “However, in vivo studies clearly demonstrate that mice with a 95% reduction in PEPCK mRNA have a nearly normal blood glucose concentration after a 24-h fast (279, 280).”
• Bile Acid Metabolism and Signaling (2013, neutral): “Accumulation of toxic endobiotics xenobiotics causes damage to cells and organs in the tract.”
• Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “Fxr knockout mice had elevated circulating and muscle free fatty acids, which explains the peripheral insulin-resistant phenotype observed in these mice (Ma et al., 2006).”
• Pleiotropic Roles of Bile Acids in Metabolism (2013, methodology): “The earlier finding that Fxr–/– mice are insulin resistant 662 Cell Metabolism 17, May 7, 2013 ª2013 Elsevier Inc. suggested a role for FXR in glucose metabolism (Cariou et al., 2006; Ma et al., 2006; Zhang et al., 2006).”
• TGR5-mediated bile acid sensing controls glucose homeostasis. (2009, background): “Instead, FXR-mediated actions of BAs appear mainly to affect liver metabolism by increasing glycogen production (Duran-Sandoval et al., 2005; Ma et al., 2006; Zhang et al., 2006) and decreasing lipogenesis and VLDL production (Watanabe et al.”
• Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR (2012, background): “Moreover, decreased plasma glucose levels with a concomitant attenuation in gluconeogenic genes was observed when FXR was activated by cholic acid in wild-type but not in Fxr -null mic”
• Targeting bile-acid signalling for metabolic diseases (2008, background): “Bile acids have been reported to inhibit gluconeogenesis via the downregulation of phosphoenolpyruvate carboxykinase ( PEPCK ) mRNA levels both in an FXR-α-dependent and FXR-α-independent manne”