Pleiotropic Roles of Bile Acids in Metabolism
By T. Q. de Aguiar Vallim, E. Tarling, P. Edwards. Cell Metabolism, 2013
1,077 citations recorded by the source corpus.
Summary Enzymatic oxidation of cholesterol generates numerous distinct bile acids that function both as detergents that facilitate digestion and absorption of dietary lipids, and as hormones that activate four distinct receptors. Activation of these receptors alters gene expression in multiple tissues leading to changes not only in bile acid metabolism, but also in glucose homeostasis, lipid and lipoprotein metabolism, energy expenditure, intestinal motility and bacterial growth, inflammation, liver regeneration and hepato-carcinogenesis. This review covers the roles of specific bile acids, synthetic agonists and their cognate receptors in controlling these diverse functions, as well as their current use in treating human diseases.
Subfields: Epidemiology, Oncology, Surgery
View Paper: https://www.semanticscholar.org/paper/10e73f0230b5563001b64cc360b0a90911e16b9a
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Citations in the corpus
- Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments (2023, background): “Beyond its synthesis and modifications of BAs after secretion (140), the gut microbiome also regulates the uptake of BAs (141).”
- Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism. (2016, neutral): “de Aguiar Vallim et al. (2013) presented details of bile acid chemistry and physiology in a recent excellent review.”
- Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. (2016, background): “Importantly, the doses of the BAs required for the inhibition of inflammasome activation were equivalent to the physiological concentrations of BAs in the portal vein (10– 80 mM) and in the peripheral circulation (2–10 mM) of humans and mice (de Aguiar Vallim et al., 2013).”
- Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, background): “Activation of AMPK increases the expression of the peroxisome proliferator-activated receptor gamma co-activator (PGC)-1 , which is known to control several transcription factors, such as peroxisome proliferator-activated receptors (PPAR , PPAR , PPAR ), the farnesoid X receptor (FXR), and the liver”