TGR5-mediated bile acid sensing controls glucose homeostasis.

By Charles Thomas, A. Gioiello, L. Noriega, Axelle Strehle, Julien Oury, G. Rizzo, A. Macchiarulo, Hiroyasu Yamamoto, C. Mataki, M. Pruzanski and 3 more. Cell Metabolism, 2009

1,753 citations recorded by the source corpus.

Subfields: Oncology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/4088b5214b87f05f629665b8315bd6a85e40171b

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In Oncology

1. Tiangang Li
2. R. Loomba
3. J. Y. Chiang
4. S. Friedman
5. David S. Wishart

In Physiology

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2. J. Y. Chiang
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4. Tiangang Li
5. Gerald I. Shulman
6. Stanley L Hazen
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In Surgery

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7. C. Bailey

Citations in the corpus

• Lipotoxicity and the gut-liver axis in NASH pathogenesis. (2018, background): “BAs have been also linked to beneficial effects on glucose metabolism mainly due to activation of TGR5 in enterocytes which leads to the release of GLP-1 and peptide tyrosine PYY that regulate food intake and glucose metabolism [155, 156].”
• Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. (2016, background): “Stimulation of TGR5 signaling confers on BAs the ability to control several physiological pathways associated with metabolic homeostasis, including the enhancement of energy expenditure (Broeders et al., 2015; Watanabe et al., 2006) and improvement of glucose tolerance (Thomas et al., 2009).”
• Dietary lipids, gut microbiota and lipid metabolism (2019, background): “In addition, TGR5 signaling induces GLP-1 release from enteroendocrine L-cells, resulting in improved liver and pancreatic function in obese mice [79], with potential influences on lipid synthesis and storage.”
• Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “In animal studies, INT-777 improves glucose tolerance, stimulates GLP-1 secretion from enteroendocrine L cells and improves insulin sensitivity, and increases intracellular ATP/ADP ratio and calcium mobilization in obese mice (Thomas et al., 2009).”
• Systemic gut microbial modulation of bile acid metabolism in host tissue compartments (2010, background): “Through this mechanism, bile acids have been found to mitigate diet-induced obesity (39).”
• Gut Microbiota in Cardiovascular Health and Disease (2017, background): “well as glucose metabolism, through FXR and GPR131.(17,18,44) In addition, some of the proatherogenic effects of TMAO are linked to reduction in reverse cholesterol transport, alteration in tissue cholesterol and sterol metabolism, and changes in BA composition, pool size, and transport in both the ”