The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing.

By Francesca De Santa, M. Totaro, Elena Prosperini, S. Notarbartolo, G. Testa, G. Natoli. Cell, 2007

951 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Sociology and Political Science

View Paper: https://www.semanticscholar.org/paper/219ae1976b3a94ce8c2e52946e051fb7f958673c

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Citations in the corpus

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm (2010, background): “These data point toward an important role for chromatin remodeling in the regulation of macrophage activatio”
Transcriptional regulation of macrophage polarization: enabling diversity with identity (2011, background): “This pathway involves the histone demethylase JMJD3 (also known as KDM6B), which functions by removing an inhibitory histone modification, H3K27me3 (Ref”
Immunity, Inflammation, and Cancer (2010, neutral): “Recently, inflammation has been connected to epigenetic reprogramming by the JmjC-domain protein Jmjd3, which is encoded by an NF-κB target gene (De Santa et al., 2007).”
Pattern recognition receptors and inflammation. (2010, background): “Trimethyl-histone 3 lysine 27 demethylase, Jmjd3, is expressed in response to TLR stimulation via NF-kB and is recruited to the transcription start sites of LPS-inducible genes (De Santa et al., 2007).”
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection (2010, background): “Proteins harboring a Jumonji-C (JmjC) domain, such as Jmjd3, Utx and Uty, are known to act as H3K27 demethylases, catalyzing the conversion of H3K27me3 (trimethylated) to H3K27me1 (monomethylated”
Single-cell RNA-seq and computational analysis using temporal mixture modelling resolves Th1/Tfh fate bifurcation in malaria (2017, background): “As reported in differentiated mouse macrophages (44), we found that human M(IFN-) macrophages expressed high HOXA1 and low HOXA9 (Fig.”
The interaction of anticancer therapies with tumor-associated macrophages (2015, background): “…for red pulp macrophages (Kohyama et al., 2009), and an increased understanding of the epigenetic landscape of resting and activated macrophages (De Santa et al., 2007; Ostuni et al., 2013; Gosselin et al., 2014; Lavin et al., 2014) will likely pave the way to an increased understanding of…”
Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages. (2010, methodology): “…were left untreated or stimulated for 2 hr with LPS. Fixation with formaldehyde and sonication was carried out as described previously (De Santa et al., 2007). p300, H3K4me1, H3K4me3, and Pu.1 ChIP lysates were generated from 2 3 108, 0.5 3 108 cells, 1 3 108, and 0.3 3 108 cells…”
Transcriptional control of the inflammatory response (2009, background): “The enzyme responsible for this activity, lysine-specific demethylase 6B ( KDM6B ; also known as JMJD3), is itself transcriptionally upregulated after LPS stimulation, and siRNA-mediated knockdown of KDM6B inhibits demethylation and the induction of Bmp2 (bone morphogenetic protein 2) expressio”
INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE (2013, positive): “Indeed, Jmjd3 is also induced in response to LPS and inflammatory cytokines to bind and regulate polycomb group target gene activity in macrophages (152).”