Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

By Subhra K. Biswas, A. Mantovani. Nature Immunology, 2010

3,752 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/2242ea323b9acd7babc4545a81cf7c978797d374

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. J. Joyce
5. J. Pollard
6. F. Balkwill
7. C. Garlanda
8. Subhra K. Biswas

Citations in the corpus

• Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy (2012, background): “Within breast cancer lesions, TAMs represent the dominant myeloid cell population and usually have an immunosuppressiveM2-like phenotype associated with the hypoxic tumor microenvironment (14, 17, 18).”
• Tumor associated macrophages and neutrophils in cancer. (2013, background): “Moreover, they suppress Th1 adaptive immunity, participate in the resolution of inflammation, in the protection against parasites, promote wound healing, angiogenesis and tissue remodeling (Biswas and Mantovani 2010).”
• Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. (2014, background): “The tumor-promoting function of TAMs is based on their capacity to secrete proangiogenic and growth factors, as well as to potently suppress T cell effector function by releasing immunosuppressive cytokines and affecting their metabolism (Wynn et al., 2013; Biswas and Mantovani 2010; Gordon and Mart”
• Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature (2012, background): “Differentiation of the M2 macrophages is induced by IL-4 or IL-13 and associated with parasite clearance, wound healing and dampen immune responses [5].”
• Pathophysiology of Myocardial Infarction (2015, neutral): “Traditionally, two major macrophage subsets are recognized (243): the classically activated M1 macrophages that predominantly secrete proinflammatory mediators, and the alternatively activated M2 macrophages that secrete anti-inflammatory cytokines (such as IL-10) and express mediators that terminat”
• The tumor microenvironment underlies acquired resistance to CSF1R inhibition in gliomas (2016, methodology): “Given the similarities in alternative activation between Veh and Reb TAMs according to the M1/M2-like paradigm (26), yet clear differences in drug response between treatment-naïve and rebound tumors, we next used a more fine-tuned approach to defining macrophage phenotype.”
• Neuroinflammation and M2 microglia: the good, the bad, and the inflamed (2014, background): “Although tumor-associated macrophages are an area of intense research [53], they are beyond the scope of this review.”
• Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation (2014, background): “…Trupti D. Gohel,1 Martina Emde,1 Lisa Schmidleithner,1 Hariharasudan Ganesan,1 Andrea Nino-Castro,1 Michael R. Mallmann,1 Larisa Labzin,2 Heidi Theis,1 Michael Kraut,1 Marc Beyer,1 Eicke Latz,2,3,4 Tom C. Freeman,5 Thomas Ulas,1 and Joachim L. Schultze1,* 1Genomics and Immunoregulation,…”