Transcriptional regulation of macrophage polarization: enabling diversity with identity

By T. Lawrence, G. Natoli. Nature reviews. Immunology, 2011

2,173 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1db4375642a9c11a973195ae34b6d0deae42ea34

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. S. Gordon
3. A. Sica
4. P. Murray
5. TA Wynn
6. P. Italiani
7. D. Boraschi
8. F. Martínez

In Molecular Biology

1. A. Mantovani
2. R. Medzhitov
3. S. Gordon
4. Y. Okabe
5. A. Sica
6. Subhra K. Biswas
7. Steffen Jung
8. A. Mildner

Citations in the corpus

• Macrophage plasticity and polarization in tissue repair and remodelling (2013, background): “These include members of the IRF/Stat families, Myc, NFκB hetero- and homo-dimers, KLF4, PPARγ, as well as miRNA and epigenetic modifications, A review of this aspect of macrophage polarization is beyond the scope of the present paper and the reader is referred to recent reviews [7,66]”
• Macrophages in Tumor Microenvironments and the Progression of Tumors (2012, background): “It has been reported that Langerhans cells in the skin and microglial cells in the brain, which are tissue-resident macrophage populations that are radiation resistant, seem to be maintained through local proliferation, and recent studies indicate that these cells initially develop from M-CFU in the”
• Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis (2012, positive): “…recently, this definition has been extended to comprise dependence of subpopulations on specific growth and transcription factors (Hashimoto et al., 2011; Lawrence and Natoli, 2011), subset-specific gene expression signatures (Robbins et al., 2008) and distinct ontogenies (Geissmann et al., 2010).”
• Macrophage activation and its role in repair and pathology after spinal cord injury. (2015, background): “For example, signaling through the transcription factors: NF-κB, STAT1, and interferon regulatory factor 5 (IRF5) drive pro-inflammatory, M1 macrophage activation (Lawrence and Natoli, 2011).”
• Macrophage regulation of tumor responses to anticancer therapies. (2013, background): “In healthy tissues, macrophages often express a mixed M1/M2 phenotype; hence ‘‘M1’’ and ‘‘M2’’ polarization should be regarded as extreme ends of a continuum of activation states, with their exact point on the scale depending on the precise mix of local signals present in a given microenvironment (B”
• An expression atlas of human primary cells: inference of gene function from coexpression networks (2013, background): “to numerous distinct stimuli with massive changes in gene expression [54].”
• Kupffer Cells in the Liver (2013, neutral): “interferon-regulatory factor 5 (IRF), while STAT6, IRF-4, and PPARγ are important transcription factors regulating M2 polarization (68).”
• Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation (2014, background): “…broader transcriptional repertoire depending on the different environmental signals received (Boorsma et al., 2013; Chow et al., 2011; Edin et al., 2012; Hodge et al., 2011; Lawrence and Natoli, 2011; Martinez et al., 2009; Mosser and Edwards, 2008; Murray and Wynn, 2011; Reinartz et al., 2013).”
• Latent enhancers activated by stimulation in differentiated cells. (2013, neutral): “This phenomenon, often indicated as plasticity, is well known in cells of the myeloid lineage such as macrophages, neutrophils, and dendritic cells, whose exposure to different stimuli results in subtypes with specific properties (Biswas and Mantovani, 2010; Fridlender et al., 2009; Lawrence and Nat”
• Macrophage activation and polarization: nomenclature and experimental guidelines (2014, positive): “…homeostasis, disease pathogenesis, and resolving and nonresolving inflammation (Biswas and Mantovani, 2010; Gordon and Martinez, 2010; Lawrence and Natoli, 2011; Mantovani et al., 2008; Mantovani et al., 2005; Martinez et al., 2008; Murray and Wynn, 2011b; Nathan and Ding, 2010; Wynn et al., 2013).”
• Macrophage polarization: An opportunity for improved outcomes in biomaterials and regenerative medicine (2012, background): “polarization and maintenance of specific macrophage phenotypes [19].”
• Tissue-specific signals control reversible program of localization and functional polarization of macrophages. (2014, positive): “Transcription factors, including STAT1, STAT6, C/EBPb, IRF-4, IRF5, and PPARg, have been shown to regulate transcription programs that control M1/M2 macrophage polarizations (Lawrence and Natoli, 2011).”