STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus.

By E. Remmers, Robert M. Plenge, Annette Lee, R. Graham, Geoffrey Hom, T. Behrens, P. D. de Bakker, J. Le, Hye-Soon Lee, F. Batliwalla and 13 more. New England Journal of Medicine, 2007

1,095 citations recorded by the source corpus.

Subfields: Oncology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/20ee6ca625a4842ee0a2915939ddc0e01a0767d5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Oncology

1. J. O’Shea
2. A. Laurence
3. P. Murray
4. I. McInnes
5. S. Gaffen

In Rheumatology

1. P. Murray
2. I. McInnes
3. J. O’Shea
4. S. Gaffen

Citations in the corpus

• Progress and Promise of Genome-Wide Association Studies for Human Complex Trait Genetics (2011, methodology): “…genotyped on the Affymetrix SNPChip 6.0 platform, three datasets genotyped on the Illumina HumanHap 317K and 550K platforms (Plenge et al. 2007; Remmers et al. 2007; Gregersen et al. 2009), and the Wellcome Trust Case Control Consortium (2007) data including nonautoimmune disease cases as…”
• Th17 cells in human disease (2008, background): “Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by autoantibodies to nuclear antigens, resulting in inflammation and damage to multiple organs.”
• JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects (2017, background): “STAT3 polymorphisms are linked to CD, psoriasis, and Behcet’s disease [62, 63], whereas RA and systemic lupus erythematosus (SLE) are associated with STAT4 polymorphisms [64], and STAT6 polymorphisms have been linked to RA, atopy, and asthma [65].”
• The genetics and immunopathogenesis of inflammatory bowel disease (2008, background): “However, although STAT3 is associated with Crohn's disease, rheumatoid arthritis is associated with STAT4 (downstream of IL-12 signalling) and not STAT3 (Ref”
• Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci (2008, background): “A recent study reported an association between SLE and variants in STAT4 (ref”
• JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. (2012, background): “IL12A and IL12RB2, which are unique to IL-12 and not shared by IL-23, and STAT4 are associated with multiple autoimmune diseases (Hirschfield et al., 2009; Mells et al., 2011; Radstake et al., 2010; Remmers et al., 2007, 2010; Trynka et al., 2011; Zhernakova et al., 2011).”
• The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention (2015, background): “STAT4 singlenucleotide polymorphisms are associated with rheumatoid arthritis (RA) and systemic lupus erythematosus (48); STAT6 single-nucleotide polymorphisms are associated with asthma and allergy (49).”
• Cytokine signaling modules in inflammatory responses. (2008, background): “Although the pathogenesis of SLE is very poorly understood, recent advances have documented that SLE and related autoimmune disorders are characterized by a transcriptional ‘‘interferon signature.’’”
• The JAK/STAT signaling pathway: from bench to clinic (2021, background): “Peficitinib is mainly investigated for treating RA.”