The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

By J. O’Shea, D. Schwartz, A. Villarino, M. Gadina, I. McInnes, A. Laurence. Annual Review of Medicine, 2015

1,413 citations recorded by the source corpus.

The Janus kinase (JAK), signal transducer of activation (STAT) pathway, discovered by investigating interferon gene induction, is now recognized as an evolutionarily conserved signaling pathway employed by diverse cytokines, interferons, growth factors, and related molecules. This pathway provides an elegant, and remarkably straightforward mechanism whereby extracellular factors control gene expression. It thus serves as a fundamental paradigm for how cells sense environmental cues and interpret these signals to regulate cell growth and differentiation. Functionally relevant genetic mutations and polymorphisms are relevant to a variety of human diseases, especially cancer and immune-related conditions. Finally, the clinical relevance of the pathway has been confirmed by the emergence of a new class of therapeutics that target JAKs.

Subfields: Cancer Research, Epidemiology, Oncology

View Paper: https://www.semanticscholar.org/paper/78e42599fdb0d693a7f6ed094a37a4d43193329c

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Citations in the corpus

• Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer (2023, background): “JAK, STAT, AND THE JAK-STAT PATHWAY The JAK-STAT pathway is an evolutionarily conserved signaling pathway activated by cytokine stimulation that enables extracellular signals to be transmitted across the cell membrane to the nucleus, causing changes in DNA transcription.(38,39) JAK-STAT signaling re”
• Inflammatory responses and inflammation-associated diseases in organs (2015, background): “The highly conserved JAK-STAT pathway involves diverse cytokines, growth factors, interferons, and related molecules, such as leptin and growth hormone, and is a signaling mechanism through which extracellular factors can control gene expression [37].”
• The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells (2017, background): “It is effective in the treatment of JAK2-gain of function mutations such as myelofibrosis, Polycythemia vera and in topical application for treatment of psoriasis [117, 119].”
• JAK–STAT Signaling as a Target for Inflammatory and Autoimmune Diseases: Current and Future Prospects (2017, background): “Different JAK-dependent cytokine receptors signal through different JAKs.”