Progress and Promise of Genome-Wide Association Studies for Human Complex Trait Genetics

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Protein–protein interaction sites are hot spots for disease‐associated nonsynonymous SNPs (2012, methodology): “The development of affordable techniques for sequencing the human genome and international efforts, such as the 1000genome and HAPmap projects [Stranger et al., 2011] are generating vast amounts of new data on common single nucleotide polymorphisms (SNPs).”
LinkImpute: Fast and Accurate Genotype Imputation for Nonmodel Organisms (2015, methodology): “Arrays are widely used for GWA studies in humans (Stranger et al. 2011) and have also been developed for several agricultural species [ e.g. , cattle (Matukumalli et al. 2009), rice (Zhao et al. 2011), grape (Myles et al. 2010), and apple (Chagné et al. 2012)].”
Genotype Imputation with Thousands of Genomes (2011, background): “5 to 5%) because interrogating such variants is a major aim of contemporary association studies (McCarthy et al. 2008; Stranger et al. 2011).”