Mitochondria-anchored receptor Atg32 mediates degradation of mitochondria via selective autophagy.

By Koji Okamoto, Noriko Kondo‐Okamoto, Y. Ohsumi. Developmental Cell, 2009

852 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1c3c1cad99e4f60510399aa2c842a51454299332

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. T. Johansen
2. T. Lamark
3. Xiao-Ming Yin
4. W. Ding
5. Yongqiang Chen
6. Koji Okamoto
7. Ivan Dikic
8. Ghazaleh Ashrafi

In Epidemiology

1. R. Youle
2. Ivan Dikic
3. T. Johansen
4. D. Klionsky
5. W. Ding
6. Xiao-Ming Yin
7. Derek P. Narendra
8. Beth Levine

In Molecular Biology

1. R. Youle
2. W. Ding
3. Xiao-Ming Yin
4. Ivan Dikic
5. T. Johansen
6. Derek P. Narendra
7. S. Jin
8. Åsa B. Gustafsson

Citations in the corpus

• PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin (2010, background): “, mammalian tissues may contain pathways orthologous to those recently identified in yeast [54,55]); the ability of the tissue to mitigate the damage by other means (a tissue composed of mitotic cells may be able to manage mitochondrial damage through cellular turnover rather than mitochondrial turn”
• The pathways of mitophagy for quality control and clearance of mitochondria (2012, methodology): “To identify factors that might account for the selectivity of mitophagy, two groups independently performed screens for yeast mutants defective in mitophagy.(41,42) Taken together, they found approximately 40 genes that were distinct from known ATGs and required for mitophagy but not bulk autophagy.”
• The regulation of autophagy – unanswered questions (2011, background): “Atg8 and LC3 are also involved in cargo recognition (Kanki et al., 2009; Noda et al., 2008; Okamoto et al., 2009; Shintani et al., 2002).”
• Mitochondria and Mitophagy: The Yin and Yang of Cell Death Control (2012, background): “The ATG32 protein is an outer mitochondrial membrane protein that interacts with ATG8 via its LC3-interacting region.(115) In mammalian cells, mitochondrial NIX/BNIP3L and BNIP3 have been identified as autophagy receptors for the selective clearance of mitochondria in cells.”
• Nix is a selective autophagy receptor for mitochondrial clearance (2010, background): “Recently, a novel mitochondrial protein, Atg32, was characterized as a selective autophagy receptor for autophagic degradation of stressed mitochondria in yeast (Kanki et al, 2009; Okamoto et al, 2009).”
• Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells (2012, methodology): “(c) HeLa cells were transfected with (Flag)N-Fundc1(1-155)-C(Myc) or (Flag)N-Fundc1(1-139)C(Myc) vectors, respectively.”
• Mechanisms of mitophagy (2011, background): “More recently, two groups independently used mitophagy screens to identify dozens of new gene products that are required for this process, some of unknown function and others with functions that were not previously linked to autophag”
• Molecular definitions of autophagy and related processes (2017, neutral): “Atg32 is the main receptor for macroautophagic responses targeting dispensable mitochondria in yeast (Kanki et al , 2009; Okamoto et al , 2009), and BCL2-like 13 (BCL2L13) has been suggested to play analogous functions in mitophagy in mouse and human cells (Murakawa et al , 2015).”