p53 Regulates Mitochondrial Respiration

By S. Matoba, Ju-Gyeong Kang, Willmar D. Patino, A. Wragg, M. Boehm, O. Gavrilova, P. Hurley, F. Bunz, P. Hwang. Science, 2006

1,700 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/1bbfede2deca0eca860c7169c013b35f491a8c7a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. C. V. Dang
2. G. Semenza
3. Ralph J. Deberardinis
4. Craig B. Thompson
5. Guido Kroemer
6. M. V. Vander Heiden
7. J. Pouysségur
8. Ping Gao

In Molecular Biology

1. C. V. Dang
2. G. Semenza
3. Guido Kroemer
4. Ralph J. Deberardinis
5. Craig B. Thompson
6. L. Galluzzi
7. David M. Sabatini
8. M. V. Vander Heiden

In Oncology

1. Guido Kroemer
2. Craig B. Thompson
3. Ralph J. Deberardinis
4. L. Galluzzi
5. Karen H. Vousden
6. David M. Sabatini
7. Douglas R. Green
8. C. V. Dang

Citations in the corpus

• Redox Regulation of Cell Survival (2008, neutral): “Furthermore, a recent report showed that the p53 tumor suppressor also affects cellular redox homeostasis by inhibiting glycolysis and stimulating mitochondrial bioenergetics through transcriptional activation of TIGAR (TP53-induced glycolysis and apoptosis regulator) and the SCO2 (synthesis of cyto”
• Cancer cell metabolism: Warburg and beyond. (2008, background): “…must either increase flux through normal ATP-generating processes, or else rely on an increased diversity of fuel sources (G). the gene encoding SCO2 (the synthesis of cytochrome c oxidase protein), which interferes with the function of the mitochondrial respiratory chain (Matoba et al., 2006).”
• Blinded by the Light: The Growing Complexity of p53. (2009, background): “For example, the ability of p53 to promote aerobic respiration appears to be critical in mice to maintain endurance during exercise (Matoba et al., 2006).”
• ROS and p53: a versatile partnership. (2008, background): “Constitutive levels of p53 are coupled to normal mitochondrial respiration through its target gene, SCO2 (synthesis of cytochrome c oxidase 2), which has a critical function in maintaining the cytochrome c oxidase complex, the major site of O2 utilization [40].”
• Tumor cell metabolism: cancer's Achilles' heel. (2008, background): “Thus, p53 positively regulates the expression of the protein synthesis of cytochrome c oxidase 2 (SCO2), which is required for assembling COX (Matoba et al., 2006). p53 negatively regulates phosphoglycerate mutase (PGM), the enzyme that converts 3-phosphoglycerate (3PG) to 2-phosphoglycerate (2PG) i”
• Anoikis molecular pathways and its role in cancer progression. (2013, background): “Loss of function of p53 or its downregulation leads to reversion of all above mentioned metabolic effects, stimulating uptake of glucose and glycolysis, but decreasing mitochondrial oxidative phosphorylation and contributing to sustain Warburg effects [153].”
• Regulation of cancer cell metabolism (2011, background): “Furthermore, p53 promotes oxidative phosphorylation by activating the expression of SCO2, which is required for the assembly of the cytochrome c oxidase complex of the electron transport chai”
• Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer (2009, background): “…glucose metabolism is a common consequence of many of the mutations responsible for human cancer, and therefore may be a central process essential for tumor growth (Flier et al., 1987; Shim et al., 1997; Osthus et al., 2000; Elstrom et al., 2004; Matoba et al., 2006; Kroemer and Pouyssegur, 2008).”
• Otto Warburg's contributions to current concepts of cancer metabolism (2011, background): “Activation of SCO2 (which regulates the cytochrome c oxidase complex) by p53 increases the efficiency of mitochondrial respiratio”
• Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009, background): “p53 also directly regulates the expression and activity of synthesis of cytochrome c oxidase 2 (SCO2) that is required for the formation of the mitochondrial cytochrome c oxidase complex (COX), which is involved in the electron transport chain of mitochondrial respiration [72].”
• Cancer Cell Metabolism: One Hallmark, Many Faces (2012, background): “SCO2 is required for correct assembly of the cytochrome c oxidase complex (COX) in the mitochondrial electron transport chain, while TIGAR is a negative regulator of the glycolytic enzyme phosphofructokinase-1 (PFK1), and thus drives glucose flux through the ox-PPP for production of ROS-titrating NA”