Cancer cell metabolism: Warburg and beyond.

By Peggy P. Hsu, David M. Sabatini. Cell, 2008

2,366 citations recorded by the source corpus.

Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg effect and establish a framework for understanding its contribution to the altered metabolism of cancer cells.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eb48a9ee1047d39abd15070d0ffa0430d74d5d8a

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Citations in the corpus

Hallmarks of cancer: the next generation. (2011, positive): “They do so in part by upregulating glucose transporters, notably GLUT1, which substantially increases glucose import into the cytoplasm (Jones and Thompson, 2009; DeBerardinis et al., 2008; Hsu and Sabatini, 2008).”
The Warburg effect in tumor progression: Mitochondrial oxidative metabolism as an anti-metastasis mechanism (2014, background): “Altered metabolism is a universal property of most, if not all, cancer cells [1] [2].”
The world of protein acetylation. (2016, background): “Cancer cells in general have a high metabolic rate [146,147].”
Shifts in growth strategies reflect tradeoffs in cellular economics (2009, background): “The models elucidate how the optimization of growth by natural selection shapes growth strategies.”
mTOR: from growth signal integration to cancer, diabetes and ageing (2010, background): “Akt promotes proliferation, survival and nutrient uptake in cancer cells (reviewed in Ref”
Metabolic regulation of hematopoietic stem cells in the hypoxic niche. (2011, background): “The tumor suppressor liver kinase B1 (Lkb1) is a serine/threonine kinase that positively regulates AMPK, which in turn senses the AMP/ATP ratio (Hsu and Sabatini, 2008).”
PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis (2012, positive): “…to function like fetal cells and to use a large fraction of glucose metabolites to synthesize macromolecules (such as amino acids, phospholipids, and nucleic acids), which support tumor cell growth (Cairns et al., 2011; Hsu and Sabatini, 2008; Koppenol et al., 2011; Vander Heiden et al., 2009).”