Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.

By Nicholas W. Bellono, J. Bayrer, Duncan B. Leitch, J. Castro, Chuchu Zhang, Tracey A. O’Donnell, S. Brierley, H. Ingraham, D. Julius. Cell, 2017

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A gut-brain neural circuit for nutrient sensory transduction (2018, background): “Similar features have been confirmed in a subset of colonic enteroendocrine cells known as enterochromaffin (11).”
Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis (2019, background): “Due to the anatomical position and function, EECs communicate with gut microbiota to send output signals in forms of hormones to afferent neurons [122, 123].”
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019, neutral): “Our results indicate that taurine can delay the excitatory-to-inhibitory developmental switch in neurons, at least in vitro, and may also act on brain function via other mechanisms (Bellono et al., 2017; Kaelberer et al., 2018).”
The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis (2018, background): “Bellono et al. (2017) have recently detailed the mechanisms involved in the communication between gut epithelial cells, particularly EECs, and the neural system by generating murine intestinal organoids where EECs were genetically tagged with green fluorescence protein to characterize their…”