Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis.

By Junjie Li, Zhiyong Yang, Bin Yu, Jun Liu, Xuemei Chen. Current Biology, 2005

832 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1859054474302d5dcb01d96d4ea9f6d1139ea4c6

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In Plant Science

Citations in the corpus

Post-transcriptional small RNA pathways in plants: mechanisms and regulations. (2006, background): “2002) RNA methylase (Li et al. 2005; Yu et al. 2005) PTGS-deficient (Boutet et al.”
Gene silencing in plants using artificial microRNAs and other small RNAs. (2008, background): “…terminal ribose position by the methyltransferase HUA ENHANCER 1 (HEN1) (Yu et al., 2005), which prevents uridylation and thus stabilizes the sRNAs (Li et al., 2005). ª 2008 The Authors Journal compilation ª 2008 Blackwell Publishing Ltd, The Plant Journal, (2008), 53, 674–690 Mechanisms of…”
Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, background): “thaliana , uridylation is known to accelerate the decay of mature miRNA, and miRNA methylation by Hen1 protects them against uridylation and degradatio”
Small RNA sorting: matchmaking for Argonautes (2010, methodology): “Processed miRNA duplexes are modified by the methyltransferase HUA ENHANCER 1 (HEN1”
Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. (2008, background): “are protected by methylation at the 30 end by methyl transferase HEN1, they are uridylated and targeted for decay (Li et al., 2005).”
Biogenesis, Turnover, and Mode of Action of Plant MicroRNAs[OPEN] (2013, background): “…(Park et al., 2002), and in the absence of methylation, the remaining miRNAs vary in size due to combined 39-end truncation and oligouridylation (Li et al., 2005). miRNA Degradation A family of SMALL RNA DEGRADING NUCLEASE (SDN) genes limits the accumulation of miRNAs in Arabidopsis…”
The widespread regulation of microRNA biogenesis, function and decay (2010, background): “In plants, 2′- O -methylation of the miRNA 3′-terminal nucleotide is a common modification; it prevents miRNA uridylation and degradatio”
Small RNAs and Their Roles in Plant Development (2009, background): “RNA Methyltransferases miRNAs and siRNAs from plants bear a 2′-O-methyl group, which protects the small RNAs from degradation and from a uridylation activity that adds a short U tail to the 3′ ends (Li et al. 2005, Yu et al. 2005).”
Plant microRNAs: new players in functional genomics (2013, neutral): “Methylation is a crucial step in miRNA biogenesis that prevents miRNA uridylation and degradation from exonuclease activity of the small RNA degrading nuclease (SDN) family (Li et al. 2005; Yu et al. 2005; Ramachandran and Chen 2008).”
Small silencing RNAs: an expanding universe (2009, neutral): “In plants, both miRNAs and siRNAs are terminally methylated, a modification that is crucial for their stabilit”
Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. (2006, background): “The untemplated uridylation of miRNAs was reminiscent of that reported for unmethylated small RNAs in Arabidopsis (Li et al., 2005). c. Cell 127, 1193–1207, December 15, 2006 ª2006 Elsevier Inc. 1195 As expected, the high-throughput reads also included some annotated C. elegans miRNAs that were not ”