Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans.

By J. Ruby, Calvin H. Jan, Christopher Player, Michael J. Axtell, William L Lee, Chad Nusbaum, Hui Ge, David P. Bartel. Cell, 2006

1,025 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fbd7254ff99c7e6e0d85812d6898ede450388052

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Citations in the corpus

PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. (2008, methodology): “ate degradation ( Ruby et al., 2006; Ohara et al., 2007; Saito et al., 2007; Horwich et al., 2007; Kirino and Mourelatos, 2007).”
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (2008, background): “2) is commonly reported in miRNA cloning studies but generally dismissed with either the sequence matching the miRBase record or the most frequently observed isomiR chosen as a reference sequence (Cummins et al. 2006; Ruby et al. 2006; Landgraf et al. 2007).”
Specificity of ARGONAUTE7-miR390 interaction and dual functionality in TAS3 trans-acting siRNA formation. (2008, background): “Given the widespread presence of 50U in animal miRNA, as well as 50U or other 50 nucleotide preferences in other small RNA classes (Ruby et al., 2006), similar AGO selectivity determinants very likely explain at least some observed 50 nucleotide biases more widely.”
Evolution of microRNA diversity and regulation in animals (2011, background): “In canonical miRNAs, there is usually only one prominent isomiR sequence (which is annotated as the mature miRNA), and all other isomiRs are produced at a much lower leve”
Next-generation DNA sequencing methods. (2008, background): “Perhaps the most profound impact of next-generation sequencing technology has been on the discovery of novel ncRNAs belonging to distinct classes in an extraordinarily diverse set of species (3, 8, 9, 18, 22, 29, 41, 55).”
piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans (2012, background): “…piRNA pathway is perfectly suited for this task, as it provides a diverse and large set ( (cid:1) 15,000) of small RNA triggers that are mismatch tolerant but do not depend on dsRNA generation (Ruby et al., 2006; Batista et al., 2008; Das et al., 2008; Wang and Reinke, 2008; Bagijn et al., 2012).”