Therapeutic potential of resveratrol: the in vivo evidence
By Joseph A. Baur, D. Sinclair. Nature reviews. Drug discovery, 2006
3,906 citations recorded by the source corpus.
Subfields: Geriatrics and Gerontology, Pathology and Forensic Medicine, Physiology
View Paper: https://www.semanticscholar.org/paper/17f4eb13d4c0a20581341fd16bbdc5b47237156d
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Citations in the corpus
- Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans (2015, background): “In vivo studies show beneficial effects [96, 97].”
- Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. (2011, background): “Resveratrol was chosen for study because of promising data (25) from animal models of cancer, heart disease, stroke, and immunity and because of data suggesting it could activate sirtuins, a class of protein deacetylases implicated in control of life span in yeast (26), flies (27), and worms (28).”
- Repeat Dose Study of the Cancer Chemopreventive Agent Resveratrol in Healthy Volunteers: Safety, Pharmacokinetics and Effect on the Insulin-like Growth Factor Axis (2010, positive): “has been demonstrated to prevent cancer, or delay its onset, in a variety of rodent models of carcinogenesis (1,2).”
- Targeting phosphoinositide 3-kinase: moving towards therapy. (2008, background): “Table) was initially characterized as phytoalexin, a toxic compound produced by higher plants [211].”
- Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan (2008, neutral): “This included neoplasias, despite the potency of resveratrol against implanted or chemically induced tumors, recently reviewed elsewhere (Baur and Sinclair, 2006).”
- Biochemical Changes throughout Grape Berry Development and Fruit and Wine Quality (2007, positive): “…it was postulated to be responsible for some of the cardioprotective effects of wine in 1992, the number of papers testing its effects both in vitro and in vivo has been increasing exponentially, and it is now linked to many of the beneficial effects of wine (reviewed by Baur and Sinclair 2006).”
- Herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function. (2011, background): “It may be relevant that most phenolic compounds have low parentmolecule bioavailability but still exhibit in vivo bioactive effects (319,320).”
- Cancer Chemoprevention Through Dietary Antioxidants: Progress and Promise (2008, positive): “That report has been followed with a battery of in vitro investigations reporting that resveratrol can prevent or slow the progression of various diseases including cancer, cardiovascular disease, and ischemic injuries (34).”
- Resveratrol: a review of preclinical studies for human cancer prevention. (2007, methodology): “For example, concentrations between 32 nM and 100 μM have been used to study various effects of resveratrol in vitro, and 100 ng– 1500 mg/kg (body weight) for animal studies (Baur and Sinclair, 2006).”
- Novel insights of dietary polyphenols and obesity. (2014, background): “As a result, the circulating concentrations of free polyphenols are even lower [175].”
- Dietary factors and low-grade inflammation in relation to overweight and obesity (2011, neutral): “This led to increased lifespan in model organisms and in animal models((280,281)).”
- The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature (2017, background): “However, while the cardiovascular protection of polyphenols appears to be better understood [37], the mechanisms of CGA on endothelial dysfunction as a major event in the development of atherosclerosis remain unclear.”
- Potential Adverse Effects of Resveratrol: A Literature Review (2020, background): “In this regard, half-life and plasma concentrations of RE metabolites in the blood were found to be 10 times higher than that of the native RE compound [58], suggesting that free RE may be locally released from these metabolites.”