Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells

By Qin Shen, Susan K. Goderie, Li-hua Jin, N. Karanth, Yu Sun, N. Abramova, P. Vincent, K. Pumiglia, Sally Temple. Science, 2004

1,579 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/176889652d64dec6919bce0534fe9c2a8a99be87

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In Cellular and Molecular Neuroscience

In Developmental Neuroscience

In Molecular Biology

Citations in the corpus

Delayed Development of Adult-Generated Granule Cells in Dentate Gyrus (2006, background): “Recent work with hippocampal progenitors demonstrates that the environment in vitro determines the phenotype of newborn cells (Song et al., 2002; Deisseroth et al., 2004; Shen et al., 2004).”
Niche-Independent Symmetrical Self-Renewal of a Mammalian Tissue Stem Cell (2005, background): “Neural stem cells appear to be sustained in a complex niche in the mammalian brain [9–11].”
A Specialized Vascular Niche for Adult Neural Stem Cells (2008, background): “Endothelial cells are a source of diffusible signals, such as VEGF, FGF2, IGF1, PEDF, BDNF, and unidentified factors that affect neural precursors (Biro et al., 1994; Jin et al., 2002; Leventhal et al., 1999; Ramirez-Castillejo et al., 2006; Shen et al., 2004).”
Adult SVZ stem cells lie in a vascular niche: A quantitative analysis of niche cell-cell interactions (2008, positive): “We have shown previously that endothelial cells release soluble factors that stimulate embryonic and adult SVZ NSC self-renewal and neurogenesis (Shen et al., 2004).”
Models, mechanisms and clinical evidence for cancer dormancy (2007, background): “However, properties of normal stem cells, such as their quiescent state within a niche that is both nurturing and protectiv”
The stem-cell niche as an entity of action (2006, background): “Endothelial cells have been implicated as directly inducing neural precursor Notch activation with resultant cell proliferation and differentiation in a manner that vascular smooth muscle cells do no”
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells (2011, background): “Though vascular sources of secreted proliferative signals are well characterized (Palmer et al., 2000; Shen et al., 2004, 2008; Tavazoie et al., 2008), the apical surfaces of early cortical precursors and their primary cilia do not approximate blood vessels but instead directly contact the…”
Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche (2007, background): “and the perivascular niche for neural stem cells and bone marrow stromal stem cell”
FAD-linked human Presenilin 1 variants impair environmental enrichment-induced hippocampal neural progenitor cell proliferation and differentiation in a non-cell-autonomous manner (2008, positive): “For example, endothelial cells have been shown to release soluble factors that stimulate the self-renewal of neural stem cells and alter their differentiation (Shen et al., 2004).”
Stem cell niche: structure and function. (2005, background): “In the neural system, the stem cell niche was found in endothelial cells located at the base of the subventricular zone (SVZ) and subgranular zone (SGZ) (Doetsch et al. 1999, Palmer et al. 1997, Shen et al. 2004).”